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Pharmacology · chapter 17 · Antidysrhythmic Drugs

Unclassified Antidysrhythmics

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. How atropine raises the heart rate

    It works as an acetylcholine receptor antagonist, thus decreasing parasympathetic or vagal regulation of the heart rate.
  2. Atropine after heart transplant

    It is important to note that heart transplant recipients lack vagal innervation, so atropine does not work to treat bradycardia in these clients.
  3. Give atropine fast

    Atropine should be administered by rapid intravenous injection. Slow administration of atropine has been associated with paradoxical bradycardia (McLendon Preuss, 2022) and should be avoided.
  4. How digoxin slows the ventricles

    As an antidysrhythmic drug, it works by suppressing conduction through the AV node, slowing the rate of conduction and, thus, the ventricular heart rate.
  5. Digoxin and kidney function

    Because it is eliminated by the kidneys and can accumulate in individuals with decreased kidney function, nurses must monitor renal function in clients who are taking digoxin.
  6. Digoxin antidote

    For clients who present with toxicity and particularly high digoxin serum levels (greater than 6–10 ng/mL), an antidote called digoxin immune fab (Digibind) can be administered to bind the digoxin and facilitate excretion.
  7. Apical pulse before digoxin

    Many health care providers monitor the apical heart rate before administering digoxin, withholding it if the apical heart rate is less than 60 beats per minute.
  8. Giving adenosine

    It must be immediately followed by a rapid saline flush. Using a stopcock can help facilitate quick administration.
  9. Expected brief asystole

    After administration of adenosine, clients will frequently experience a brief period of asystole on the ECG while concurrently experiencing a sensation of their heart stopping.
  10. Prepare the client for adenosine

    The nurse should tell the client about this expected effect to mitigate anxiety when the effect occurs.
  11. Serious atropine adverse effects

    Some of the more serious adverse effects include tachycardia, acute glaucoma, pyloric obstruction, complete urinary retention in clients with benign prostatic hyperplasia, and formation of respiratory mucus plugs.
  12. Signs of digoxin toxicity

    Digoxin therapy has a propensity for toxicity, which is characterized by gastrointestinal upset, vision changes, dizziness, fatigue, and cardiovascular symptoms such as palpitations from premature ventricular contractions (Cummings Swoboda, 2023).
  13. What clients feel with adenosine

    However, immediately upon administration it is typical for clients to report skin flushing, sweating, nausea, and an impending sense of doom.
  14. Adenosine contraindications

    Adenosine should not be administered to clients with second- or third-degree AV block or to those with bradycardia who do not have a pacemaker.

Terms to know

Atropine
Atropine Atropine is an anticholinergic agent approved for symptomatic bradycardia, among other indications.
Adenosine
Adenosine Adenosine is another unclassified antidysrhythmic drug that is approved for treating paroxysmal supraventricular tachycardia.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A nurse is about to give digoxin to a client with atrial fibrillation. The apical heart rate is 56 beats per minute. What should the nurse do?

    1. Withhold the dose and notify the health care provider.
    2. Give the dose with extra fluids.
    3. Give the dose and recheck in an hour.
    4. Give the dose and have the client lie flat.

    Answer: Withhold the dose and notify the health care provider.

    Digoxin slows the heart rate, and it is commonly withheld when the apical rate is below 60 beats per minute. The other options still give a drug that will slow the rate further.

  2. A nurse is giving adenosine for paroxysmal supraventricular tachycardia. Which technique is correct?

    1. Give it intramuscularly into the deltoid.
    2. Mix it in a 250 mL bag and infuse over an hour.
    3. Give it as a rapid IV bolus close to the client, followed immediately by a rapid saline flush.
    4. Give it slowly over 10 minutes through a central line.

    Answer: Give it as a rapid IV bolus close to the client, followed immediately by a rapid saline flush.

    Adenosine's half-life is under 10 seconds, so it is pushed rapidly into a peripheral IV as close to the client as possible and followed at once by a rapid saline flush. Slow, diluted or intramuscular routes let it be metabolized before it reaches the heart.

  3. Seconds after an adenosine push, the monitor shows a brief flat line and the client says, "I feel like my heart stopped." What does the nurse recognise?

    1. An expected, short-lived effect of adenosine
    2. A sign that the dose was too small
    3. An allergic reaction to the drug
    4. Digoxin toxicity

    Answer: An expected, short-lived effect of adenosine

    Brief asystole with a sensation of the heart stopping is expected after adenosine because AV conduction is blocked briefly; it is short lived due to the very short half-life. It does not indicate allergy, underdosing, or digoxin toxicity.

  4. A client taking digoxin calls the clinic. Which reported symptoms could indicate digoxin toxicity? Select all that apply.

    1. Palpitations
    2. Nausea and stomach upset
    3. Dizziness and fatigue
    4. Changes in vision
    5. Increased appetite

    Answer: Palpitations, Nausea and stomach upset, Dizziness and fatigue, Changes in vision

    Digoxin toxicity shows as gastrointestinal upset, vision changes, dizziness, fatigue and palpitations from premature ventricular contractions. Increased appetite is not listed; anorexia is an adverse effect.

  5. Atropine is being considered for a client with symptomatic bradycardia. Which findings in the history should the nurse report to the provider? Select all that apply.

    1. Recent ankle sprain
    2. Heart transplant
    3. Myasthenia gravis
    4. Seasonal allergies
    5. Urinary retention

    Answer: Heart transplant, Myasthenia gravis, Urinary retention

    Atropine may not work after heart transplant because vagal innervation is lost, and its anticholinergic effects can worsen myasthenia gravis and urinary retention. Allergies and a sprain are not concerns in the section.

  6. A client going home on digoxin also has chronic kidney disease. Why does the nurse monitor renal function?

    1. Kidney function affects only IV digoxin.
    2. Digoxin improves kidney function, so the dose must rise.
    3. Digoxin directly damages the kidneys.
    4. Digoxin can accumulate when kidney function is decreased.

    Answer: Digoxin can accumulate when kidney function is decreased.

    Digoxin is eliminated by the kidneys, so it accumulates when kidney function falls and toxicity becomes more likely. The section does not describe direct kidney damage, improved kidney function, or a route-only effect.

Where every quote comes from

Section 17.6 Unclassified Antidysrhythmics of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.