Pharmacology · chapter 17 · Antidysrhythmic Drugs
Class IV: Calcium Channel Blockers
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Calcium in the SA and AV nodes
It flows into the cells of the SA node (the pacemaker of the heart) and AV node to mediate the heart rate and conduct electrical signals from the atria to the ventricles.
What non-DHP blockers do
They inhibit calcium channels in cardiac cells, resulting in a slower heart rate, slower conduction through the AV node, and a decreased force of contraction.
Rate control in atrial fibrillation
Calcium channel blockers are useful for slowing the heart rate in clients with atrial fibrillation with rapid ventricular response because they slow down the conduction of abnormal impulses through the AV node, thus decreasing the rate at which the ventricles are prompted to contract.
Check heart rate and blood pressure
The nurse must monitor the baseline heart rate and blood pressure before administering a calcium channel blocker and then monitor them frequently during therapy.
Heart rate below 60
If the baseline heart rate is less than 60 beats per minute, consider checking with the health care provider before administration.
DHP blockers do not treat dysrhythmias
Another class of calcium channel blockers, the DHP calcium channel blockers, block calcium channels only within arteries, not within the heart. Therefore, DHP calcium channel blockers are useful for treating hypertension but not for treating dysrhythmias.
Diltiazem products are easily confused
Many different companies manufacture oral diltiazem as similar but not bioequivalent generic products, which can lead to confusion during prescribing and administration.
Take an exact medication history
The nurse should take an accurate medication history with the specific medication the client takes and be careful to avoid confusing the various products.
Verapamil indications
Verapamil Verapamil is a non-DHP calcium channel blocker approved for the treatment of angina, atrial fibrillation/atrial flutter, hypertension, and supraventricular tachycardia.
Bradycardia as an extension of effect
Calcium channel blockers can cause bradycardia as an extension of their therapeutic effect. They also decrease arterial vasoconstriction, which reduces blood pressure and can cause hypotension.
Reduced contractility in heart failure
This can be particularly troublesome in clients with heart failure with reduced ejection fraction or acute myocardial infarction, who already have decreased contractility. For this reason, non-DHP calcium channel blockers should be used cautiously or avoided in those clients.
Avoid with heart block or beta blockers
They should also be avoided in clients who have bradycardia or AV blocks without a pacemaker or those receiving beta-adrenergic blockers.
Continuous monitoring on IV drugs
Use continuous cardiac/hemodynamic monitoring in clients on intravenous calcium channel blockers.
Symptoms to report
Contact their health care provider if they experience signs or symptoms of adverse effects of the medication, such as dizziness or lightheadedness (which could indicate hypotension) or edema.
Terms to know
- nondihydropyridine
- Antidysrhythmic calcium channel blocker s are class IV Vaughan Williams drugs and are also known as nondihydropyridine (non-DHP) calcium channel blockers.
- Diltiazem
- Diltiazem Diltiazem is a non-DHP calcium channel blocker antidysrhythmic.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client with atrial fibrillation is due for oral diltiazem. The nurse finds a heart rate of 54 beats per minute and the client has no pacemaker. What should the nurse do?
- Give the dose with grapefruit juice.
- Give the dose and have the client walk to raise the heart rate.
- Give the dose as scheduled.
- Check with the health care provider before giving the dose.
Answer: Check with the health care provider before giving the dose.
Calcium channel blockers slow the heart rate, so with a baseline rate under 60 and no pacemaker, the nurse checks with the provider first. Giving the dose would slow the rate further, and grapefruit juice should be avoided.
A client asks why their blood pressure pill, a DHP calcium channel blocker, will not control their atrial fibrillation. Which explanation is accurate?
- DHP calcium channel blockers only work intravenously.
- DHP calcium channel blockers act only on arteries, not on the heart.
- DHP calcium channel blockers are too weak to work at all.
- DHP calcium channel blockers speed up the heart.
Answer: DHP calcium channel blockers act only on arteries, not on the heart.
DHP calcium channel blockers block calcium channels only within arteries, so they treat hypertension but not dysrhythmias. The other statements are not supported by the section.
A client is admitted and says they take "Cardizem, the long-acting one". What is the nurse's best action?
- Substitute any extended-release diltiazem on the unit.
- Switch the client to verapamil.
- Hold all heart medications until discharge.
- Identify the exact product the client takes.
Answer: Identify the exact product the client takes.
Oral diltiazem generics are similar but not bioequivalent, so the nurse takes an accurate history of the specific product and avoids confusing them. Substituting, holding everything, or switching drugs are not supported.
A nurse reviews the chart of a client prescribed IV diltiazem. Which findings should prompt the nurse to question the order? Select all that apply.
- Hypertension
- Heart failure with reduced ejection fraction
- Atrial fibrillation with rapid ventricular response
- Currently receiving a beta-adrenergic blocker
- AV block without a pacemaker
Answer: Heart failure with reduced ejection fraction, Currently receiving a beta-adrenergic blocker, AV block without a pacemaker
Non-DHP calcium channel blockers reduce contractility and slow conduction, so they are used cautiously or avoided in reduced-ejection-fraction heart failure, AV block without a pacemaker, and with beta blockers. Rapid atrial fibrillation and hypertension are indications.
Which teaching points should the nurse include for a client going home on verapamil? Select all that apply.
- Stop the medication if the ankles swell a little.
- Keep an up-to-date medication list and bring it to appointments.
- Report dizziness, lightheadedness or swelling.
- Report a racing heart or fatigue.
- Avoid drinking grapefruit juice.
Answer: Keep an up-to-date medication list and bring it to appointments., Report dizziness, lightheadedness or swelling., Report a racing heart or fatigue., Avoid drinking grapefruit juice.
Clients avoid grapefruit juice, report adverse effects such as dizziness and edema, report signs of therapeutic failure such as a racing heart, and keep a medication list to prevent interactions. Stopping the drug on their own is not in the teaching; edema is reported.
A client is receiving an intravenous diltiazem infusion for atrial fibrillation. Which nursing action is required?
- Use continuous cardiac and hemodynamic monitoring.
- Check the blood glucose every hour.
- Monitor only the urine output.
- Check vital signs once per shift.
Answer: Use continuous cardiac and hemodynamic monitoring.
Clients on intravenous calcium channel blockers need continuous cardiac and hemodynamic monitoring because the drugs lower heart rate and blood pressure. Once-per-shift checks are too infrequent, and glucose or urine output alone do not track these effects.
Where every quote comes from
Section 17.5 Class IV: Calcium Channel Blockers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.