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Pharmacology · chapter 1 · Introduction to Pharmacology

Drug Classifications and Prototypes

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 4 practice questions with the reasoning.

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Key points

  1. Two classification methods

    Most drugs are classified in two ways—therapeutic classification and pharmacologic classification.
  2. Therapeutic classification basis

    Therapeutic classification refers to a drug’s therapeutic use or clinical indication (the diagnosis or disease being treated).
  3. Therapeutic effect meaning

    When using a therapeutic classification, one describes the therapeutic effect, or the clinical result that occurs after the client takes a drug.
  4. Pharmacologic classification basis

    Pharmacologic classification refers to how the drug works in the body—its mechanism of action.
  5. Multiple therapeutic classifications

    Even though a drug may have more than one therapeutic classification, such as the previous example of metoprolol being both an antianginal and an antihypertensive, it will essentially have the same mechanism of action (though its targeted effect may be different), side effects, and safety parameters.
  6. Classification helps nurses

    Knowledge of a drug’s classification helps the nurse understand its intended effects and its adverse effects.
  7. Prototype class representative

    Once drugs are sorted into classifications, it is customary to utilize one drug within the class to compare to all the other drugs within that class.
  8. Prototype learning value

    Using a drug prototype is helpful for an individual learning pharmacology because it makes learning much more manageable.
  9. Applying prototype knowledge

    When a health care provider orders the beta-adrenergic blocker atenolol, that nurse knows it will have a similar mechanism of action, side effects, and safety parameters as metoprolol.
  10. Controlled Substances Act purpose

    In 1970, Congress passed the Controlled Substances Act, which led to the establishment of the DEA in 1973 and described the controls for manufacturing, distributing, and prescribing habit-forming drugs.
  11. Controlled substance scheduling

    This legislation not only categorized controlled substances based on their potential for abuse but also established drug schedules and provided drug treatment programs for those with addictions.
  12. Required controlled drug records

    All hospitals and pharmacies must keep records of drugs purchased and sold.
  13. DEA prescriber registration

    Any health care provider with prescriptive authority must be registered with the DEA and given a unique DEA identifier that they must place on any controlled substance prescription.
  14. Schedule I restrictions

    As noted in Table 1.4, Schedule I drugs have no medical use and a very high potential for abuse and physical/psychological dependency; therefore, most health care providers cannot issue prescriptions for those drugs, and pharmacies cannot fill those prescriptions.

Terms to know

Therapeutic classification
Therapeutic classification refers to a drug’s therapeutic use or clinical indication (the diagnosis or disease being treated).
therapeutic effect
When using a therapeutic classification, one describes the therapeutic effect, or the clinical result that occurs after the client takes a drug.
Pharmacologic classification
Pharmacologic classification refers to how the drug works in the body—its mechanism of action.
drug prototype
It becomes the “class representative,” known as the drug prototype.
Schedule V drugs
Schedule V drugs are those with the lowest potential for misuse and dependency (U.S. DEA, n.d.).

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client is prescribed metoprolol for chest discomfort associated with coronary artery disease and also has elevated blood pressure. The client asks why the same drug is listed as both an antianginal and an antihypertensive. Which response by the nurse is best?

    1. One of the classifications must be incorrect because a drug can have only one therapeutic classification.
    2. The drug can have more than one therapeutic classification because it is used for different clinical indications, while its mechanism of action remains essentially the same.
    3. The drug changes pharmacologic classification depending on which diagnosis is being treated.
    4. The two therapeutic classifications mean the nurse should expect two different sets of side effects and safety parameters.

    Answer: The drug can have more than one therapeutic classification because it is used for different clinical indications, while its mechanism of action remains essentially the same.

    Therapeutic classification is based on the drug’s clinical use, so one drug may have more than one therapeutic classification. The section explains that even with multiple therapeutic classifications, the drug essentially has the same mechanism of action, side effects, and safety parameters.

  2. A nurse who is very familiar with metoprolol receives an order for atenolol, another beta-adrenergic blocker. Which action best reflects use of the prototype approach?

    1. Disregard safety parameters because prototypes are used only to identify therapeutic indications.
    2. Use knowledge of metoprolol to anticipate that atenolol will have a similar mechanism of action, side effects, and safety parameters.
    3. Assume atenolol must have the same dosage quantity, frequency, and route as metoprolol.
    4. Treat atenolol as unrelated to metoprolol because prototypes are helpful only in textbooks, not clinical practice.

    Answer: Use knowledge of metoprolol to anticipate that atenolol will have a similar mechanism of action, side effects, and safety parameters.

    The prototype approach uses one representative drug to help understand other drugs in the same class. The section specifically describes applying knowledge of metoprolol to atenolol because both are beta-adrenergic blockers.

  3. A nurse is auditing controlled-substance prescribing and documentation procedures in a hospital pharmacy. Which findings are consistent with the federal controls described in the section? Select all that apply.

    1. A controlled substance prescription includes the prescriber’s unique DEA identifier.
    2. A health care provider with prescriptive authority is registered with the DEA.
    3. The pharmacy fills routine Schedule I prescriptions because Schedule I drugs have no accepted medical use.
    4. Schedule II, III, and IV prescriptions are linked to a medically sound reason.
    5. The hospital and pharmacy keep records of drugs purchased and sold.

    Answer: A controlled substance prescription includes the prescriber’s unique DEA identifier., A health care provider with prescriptive authority is registered with the DEA., Schedule II, III, and IV prescriptions are linked to a medically sound reason., The hospital and pharmacy keep records of drugs purchased and sold.

    The section states that hospitals and pharmacies must keep purchase and sale records, and prescribers must be registered with the DEA and use a unique DEA identifier on controlled substance prescriptions. It also states that Schedule II, III, and IV drugs require a medically sound reason; Schedule I prescriptions generally cannot be issued or filled.

  4. A nurse is teaching new staff why a routine prescription for a Schedule I drug should not be expected to be filled by a pharmacy. Which explanation is most accurate?

    1. Schedule I drugs have general medical use but must be prescribed only with a DEA identifier.
    2. Schedule I drugs have no medical use and a very high potential for abuse and dependency, so most providers cannot prescribe them and pharmacies cannot fill those prescriptions.
    3. Schedule I drugs may be prescribed when there is a medically sound reason, similar to Schedule II, III, and IV drugs.
    4. Schedule I drugs have the lowest potential for misuse and dependency, so prescriptions are limited to special pharmacies.

    Answer: Schedule I drugs have no medical use and a very high potential for abuse and dependency, so most providers cannot prescribe them and pharmacies cannot fill those prescriptions.

    Schedule I drugs are described as having no accepted medical use and a very high potential for abuse and dependency. Because of this, most health care providers cannot issue prescriptions for them, and pharmacies cannot fill those prescriptions.

Where every quote comes from

Section 1.3 Drug Classifications and Prototypes of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.