Pharmacology · chapter 1 · Introduction to Pharmacology
Special Considerations
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Medication costs burden
A larger share of health care costs has been passed on to the consumer in the form of out-of-pocket expenses as health care costs have risen.
Chronic illness nonadherence
Although there are many medications that can treat these conditions, half of all clients do not take their medications as prescribed.
Insurance and adherence
A lack of insurance coverage does impact the likelihood of medication non-adherence. So, not only do more chronic medical conditions occur in individuals living in reduced circumstances, but those same circumstances prevent them from managing their care appropriately.
Formulary limits access
Not all drugs will be included on an insurance plan’s formulary, meaning the client may be responsible for the cost of specific drugs or switch to an alternative agent.
Assess financial barriers
The nurse should identify and investigate barriers to any health care provider or clinic visits, treatments, or needed medication. Use simple, nonjudgmental language to discuss the client’s financial concerns.
Age-related drug sensitivity
The very young and the very old are predisposed to be the most sensitive to drugs. One factor causing this is the differences in pharmacokinetics in these individuals.
Pediatric dose accuracy
Pediatric dosing is sometimes calculated by milligrams per kilogram (mg/kg) of body weight or by body surface area (BSA). It is essential to be very accurate when calculating pediatric doses.
Pediatric research limits
One of the challenges with drugs in pediatric clients is the limited testing when researching the drug. Almost all information about drugs, in general, is related to dosing in the adult client.
Body size dosing
A client with overweight or obesity may require a larger dose to obtain the intended effect, whereas an undernourished client may need a smaller dose. This is one reason that accurate height and weight are so important in the physician’s office or clinical setting.
Pregnancy risk balance
The benefit to the pregnant client and fetus should always be weighed against the risk of treatment. This can be very challenging in clinical practice.
Placental drug passage
Some drugs pass through the placenta to the fetus, though others are blocked. Several factors determine drug passage across the placenta (e.g., lipid-soluble drugs will pass more easily than those bound to proteins).
Pregnancy medication assumption
The nurse should always assume that any medication taken during pregnancy can reach the fetus.
No pregnancy drug safety
Even drugs that are generally considered “safe” during pregnancy may carry some risk—no drug can be considered 100% safe to use during pregnancy.
Older adult adverse reactions
Adverse drug reactions occur more frequently in the older population and frequently cause hospital admissions and readmissions. Some of the factors that cause this increase are polypharmacy (taking many drugs), treatment with drugs that have a narrow safety margin, and multiple chronic conditions.
Terms to know
- pharmacoeconomics
- The field of pharmacoeconomics probes into the analysis of the costs of drug therapy to health care systems and society as a whole, and it examines the consequences of providing pharmacological products and services to clients.
- deductible
- Some insurance plans also have a deductible, which means that the client must pay a certain amount of money “out-of-pocket” before the insurance begins to pay for medications.
- Pharmacokinetics
- Pharmacokinetics is the movement of a drug through the body.
- teratogenic
- If a drug is known to cause fetal harm through embryonic or fetal development, it is said to be teratogenic.
- Intangible costs
- Intangible costs are due to an illness but are difficult to measure, such as the cost of loss, pain, or suffering.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
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A client with a chronic condition reports taking a prescribed medication only when money is available. Which nursing actions are appropriate? Select all that apply.
- Explore whether the client has health insurance.
- Tell the client that medication adherence is mainly a matter of personal responsibility.
- Use simple, nonjudgmental language when discussing financial concerns.
- Ask about barriers to provider visits, treatments, or needed medication.
- Collaborate with pharmacy or social work to develop a plan that meets the client’s needs.
Answer: Explore whether the client has health insurance., Use simple, nonjudgmental language when discussing financial concerns., Ask about barriers to provider visits, treatments, or needed medication., Collaborate with pharmacy or social work to develop a plan that meets the client’s needs.
The section emphasizes that socioeconomic factors can prevent clients from obtaining care and taking medications as prescribed. The nurse should investigate barriers, discuss finances without judgment, ask about insurance, and collaborate with other disciplines rather than blaming the client.
The nurse is preparing a small prescribed medication dose for an infant. Which action best promotes safe administration?
- Use the smallest syringe available for the specific dose.
- Skip rechecking the calculation if the dose was prescribed electronically.
- Base the dose on typical adult dosing information.
- Use a larger syringe because it is easier to hold.
Answer: Use the smallest syringe available for the specific dose.
Pediatric clients require very accurate dosing because of their smaller body mass and age-related pharmacokinetic differences. The section specifically identifies using the smallest syringe available as a safety measure for more precise measurement.
A pregnant client asks whether a newly prescribed medication could affect the fetus. Which responses by the nurse are consistent with the section? Select all that apply.
- Teach that no drug can be considered 100% safe to use during pregnancy.
- Explain that a known teratogen will always cause harm to every fetus.
- Weigh the benefit to the pregnant client and fetus against the risk of treatment.
- Assume that any medication taken during pregnancy can reach the fetus.
- Explain that lack of safety data proves the medication will not cause harm.
Answer: Teach that no drug can be considered 100% safe to use during pregnancy., Weigh the benefit to the pregnant client and fetus against the risk of treatment., Assume that any medication taken during pregnancy can reach the fetus.
The nurse should approach medication use in pregnancy cautiously, assuming fetal exposure is possible and weighing benefits against risks. Lack of data does not prove safety, and even known teratogens do not always harm every fetus.
An older adult takes several prescription medications and sees multiple providers. During a clinic visit, which nursing action is the priority for reducing drug-related problems?
- Ask only about medications prescribed by the provider at this clinic.
- Take a complete drug history at the encounter, including how each drug was prescribed.
- Encourage the client to stop any medication that causes an unpleasant effect.
- Assume medication use is accurate if the client brought a medication list.
Answer: Take a complete drug history at the encounter, including how each drug was prescribed.
Older adults are at increased risk for drug-related problems, especially when taking multiple medications. The section directs nurses to take a complete drug history at each encounter and verify medication use rather than making assumptions or advising independent discontinuation.
A client has limited English proficiency, and a family member offers to translate during medication teaching. Which nursing actions are appropriate? Select all that apply.
- Avoid using a family member to translate when possible.
- Consult someone knowledgeable about the client’s cultural history, but verify beliefs with the client.
- Engage an interpreter because the client’s use of English is limited.
- Provide health information in the client’s primary language when possible.
- Assume the client’s beliefs based on what is typical for the client’s cultural group.
Answer: Avoid using a family member to translate when possible., Consult someone knowledgeable about the client’s cultural history, but verify beliefs with the client., Engage an interpreter because the client’s use of English is limited., Provide health information in the client’s primary language when possible.
The section emphasizes culturally humble communication, including use of an interpreter, avoiding family translation when possible, and providing information in the client’s primary language. Cultural information can guide care, but beliefs should be verified with the individual client rather than assumed.
A client with significant weight changes is prescribed a medication calculated in milligrams per kilogram. Which nursing action is most important before administration?
- Obtain accurate current height and weight information.
- Use the client’s previously documented weight to avoid delaying the dose.
- Ask whether the client feels the medication dose is too high or too low.
- Assume the same dose is appropriate because the medication was already prescribed.
Answer: Obtain accurate current height and weight information.
Body size affects drug response and many drugs are calculated by body weight. Accurate height and weight are therefore important to support correct dosing and the intended therapeutic effect.
Where every quote comes from
Section 1.4 Special Considerations of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.