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Pharmacology · chapter 1 · Introduction to Pharmacology

Drug Sources, Forms, and Names

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. Drug source variety

    As mentioned previously, drugs come from a variety of resources—plants, animal products, and inorganic substances.
  2. Biologics targeted therapy

    Biologics offer the advantage of more targeted therapy for specific diseases, such as autoimmune disorders and cancer, with the potential for fewer side effects, but they are uniquely formulated with complex pharmacotherapy and may require administration through infusions or injections, which adds to the cost of treatment.
  3. Biosimilar molecular structure

    However, the essential difference between a biosimilar and a generic medication is in the drug’s molecular structure. Biosimilar drugs have a larger and more complex molecular structure than generic drugs and are made from a living organism such as yeast or bacteria (U.S. Food and Drug Administration [FDA], 2022c).
  4. Enteral drug forms

    The most common forms for these routes are through capsules and tablets (both may be sustained release), caplets, elixirs, emulsions, lozenges, suspensions, and syrups.
  5. Crushing time-release medications

    Time-release capsules or tablets and enteric-coated tablets should not be crushed or chewed. Generally, these capsules should also not be opened and emptied onto food because this will alter how quickly the drug is absorbed.
  6. Parenteral onset and dose

    The onset of action is often more rapid than with oral administration; however, the duration of action is usually shorter. Because these drugs do not have to travel through the stomach and be metabolized in the liver, the dose is usually smaller than with oral dosing.
  7. Intravenous absorption

    There are no barriers to absorption for intravenous medications because these drugs are injected directly into the bloodstream—absorption is immediate and complete.
  8. Drug name categories

    There are three basic methods for identifying a drug—the chemical name, the generic name, and the brand name, or trade name.
  9. Generic names and safety

    Though brand names are frequently used in the clinical setting, generic names are preferred for safety reasons. Generic names are also incorporated into the National Council Licensure Examination (NCLEX); therefore, it is helpful to learn the generic names of medications before sitting for a licensure exam.
  10. Generic drug approval testing

    The thing to remember is that rigorous testing must be performed to show that the generic drug form behaves in the human body in a similar manner to the brand name that it is patterned after—if it does not, it will not be approved by the FDA.
  11. Prescription communication

    The prescription communicates the provider’s plan for the client and drug to the nurse or the pharmacist.
  12. OTC drug risks

    Over-the-counter drugs may still carry risks to the client. They are safe only if taken as recommended on the drug label.
  13. Medication history importance

    Many clients do not consider OTC drugs as medication and will not always report the use of these drugs. When taking a drug history, listing all dietary supplements and OTC drugs is crucial to prevent interactions.
  14. USP-NF drug standards

    It produces the only official book of drug standards in the United States annually, and drugs referenced in this book have met very high standards for quality, strength or potency, and purity (U.S. Pharmacopeia, n.d.).

Terms to know

Drugs
Drugs are substances or compounds that prevent, treat, diagnose, or cure various conditions or diseases.
Biologics
Biologics are medications that come from a living source and are developed through a combination of biomolecular science, immunology, and genetic engineering.
synthetic drugs
Chemical compounds produced in a laboratory either commercially by a drug manufacturer or illegally by individuals producing drugs for illicit reasons are called synthetic drugs.
Enteral medications
Enteral medications are drugs administered into the gastrointestinal (GI) tract.
Prescription medications
Prescription medications are drugs available to the client only by an order (commonly known as a prescription) from a health care provider.
Over-the-counter (OTC) drugs
Over-the-counter (OTC) drugs are available without a prescription to the public.
Alternative medicine
Alternative medicine refers to using a treatment instead of mainstream conventional medicine, whereas complementary therapy refers to using both alternative medicine and conventional medicine together.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client has difficulty swallowing and asks the nurse to crush an enteric-coated tablet and mix it with applesauce. What is the nurse’s best response?

    1. Crush the tablet because enteral medications are intended for the GI tract.
    2. Hold all enteral medications because dysphagia requires parenteral administration.
    3. Do not crush the tablet; verify with the pharmacist or prescriber before changing how it is taken.
    4. Open or crush the medication only if the client agrees to take it immediately.

    Answer: Do not crush the tablet; verify with the pharmacist or prescriber before changing how it is taken.

    Enteric-coated and time-release preparations should not be crushed or chewed because doing so can change how quickly the drug is absorbed. The section also notes that opening some formulations can cause an overdose or a subtherapeutic dose, so the nurse should ask before attempting this.

  2. A client is nauseated, vomiting, and needs a medication delivered quickly. Which route would the nurse expect the provider to prescribe?

    1. Parenteral injection
    2. Oral tablet
    3. Enteric-coated tablet
    4. Lozenge

    Answer: Parenteral injection

    The parenteral route is often used when rapid drug delivery is needed and is helpful when the client has nausea or vomiting. Oral tablets, enteric-coated tablets, and lozenges are enteral forms that must go through the GI tract, which is not helpful when vomiting is present.

  3. The nurse is obtaining a medication history from a client. Which items should the nurse specifically ask the client to list? Select all that apply.

    1. Herbal products
    2. Only medications covered by insurance
    3. Over-the-counter pain or fever reducers
    4. Dietary supplements
    5. Only medications prescribed by a health care provider

    Answer: Herbal products, Over-the-counter pain or fever reducers, Dietary supplements

    The section emphasizes that OTC drugs, dietary supplements, herbals, and supplements must be included because they can interact with other therapies. Asking only about prescriptions or insurance-covered drugs could miss important safety risks.

  4. A client reports alternating Advil and Motrin because “they are different brands, so they must be different drugs.” What teaching should the nurse provide?

    1. The chemical name is the name the client should use to prevent medication errors.
    2. Brand names are always safer than generic names.
    3. Advil and Motrin are different brand names for the same generic drug, ibuprofen.
    4. A drug can have many generic names but only one brand name.

    Answer: Advil and Motrin are different brand names for the same generic drug, ibuprofen.

    The section explains that the generic name remains the same even when different companies sell the drug under different brand names. Teaching the client to recognize the generic name helps prevent taking duplicate products.

  5. A nurse reviews a prescription for a controlled substance and notices the prescriber’s DEA number is missing. What is the nurse’s priority action?

    1. Replace the missing DEA number with the prescriber’s phone number.
    2. Process the prescription because the client’s name and dose are present.
    3. Ask the client to provide the DEA number.
    4. Clarify the prescription because a DEA number is required for controlled substances.

    Answer: Clarify the prescription because a DEA number is required for controlled substances.

    The section lists the DEA number as required information for controlled substances. The nurse should not process the prescription as complete or substitute other information for the missing DEA number.

  6. A client asks why a biosimilar medication is not simply called a generic version of a biologic. Which statements by the nurse are accurate? Select all that apply.

    1. Generic medications usually require the same research and development protocols as the original company’s drug.
    2. Biosimilar drugs have larger and more complex molecular structures than generic drugs.
    3. A generic drug manufacturer must demonstrate bioequivalence to the brand-name drug.
    4. A biosimilar manufacturer must demonstrate that the drug is similar to the biologic reference drug.
    5. Biosimilars are considered bioequivalent because their manufacturing processes are simple.

    Answer: Biosimilar drugs have larger and more complex molecular structures than generic drugs., A generic drug manufacturer must demonstrate bioequivalence to the brand-name drug., A biosimilar manufacturer must demonstrate that the drug is similar to the biologic reference drug.

    Generics and biosimilars are evaluated differently: generics must show bioequivalence, while biosimilars must show similarity to the reference biologic. Biosimilars are also larger, more complex molecules made from living organisms, so they are not considered the same as generic drugs.

Where every quote comes from

Section 1.2 Drug Sources, Forms, and Names of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.