Pharmacology · chapter 38 · Ophthalmic Drugs
Ocular Anti-inflammatories and Anti-infectives
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Ocular NSAIDs and bleeding
The potential exists for prolonged bleeding due to interference with the aggregation (clumping) of thrombocytes (platelets). Blood can enter the aqueous humor, resulting in a hyphema (a collection of blood in the anterior chamber of the eye).
Stop NSAIDs if the cornea breaks down
Clients who exhibit evidence of corneal epithelial breakdown should immediately discontinue use of the topical NSAIDs and must be closely monitored to ensure proper healing of the cornea.
NSAIDs weaken latanoprost
Combining any ophthalmic NSAID with latanoprost will diminish the therapeutic effect of latanoprost. Ocular NSAIDs are contraindicated for clients with a history of severe NSAID or acetylsalicylic acid (aspirin) hypersensitivity.
Cyclosporine plus steroids and infection
If topical corticosteroids are given concurrently with cyclosporine, this can increase the chances of infection because both drugs can decrease the immune response.
Sulfites in some dexamethasone forms
Some dexamethasone dosage forms contain a sulfite that may cause an asthmatic episode or an allergic reaction ranging from urticaria to life-threatening anaphylaxis in those who have a sensitivity to sulfites (DailyMed, Maxidex, 2006).
Check IOP with prolonged steroid use
Extended use may cause increased IOP, which may result in glaucoma. Anyone using these products for more than 10 days should routinely have their intraocular pressure checked.
Steroids and active infection
Many viral, bacterial, and fungal infections of the cornea or conjunctiva may be exacerbated; therefore, corticosteroids are contraindicated in those with an active infection (DailyMed, Prednisolone, 2023).
Taper ocular steroids as prescribed
The client taking an ocular corticosteroid should: Follow the tapering instructions given by the prescriber to avoid adrenal gland insufficiency.
Contagious for 24–48 hours
Topical antibacterials are used to treat ophthalmic infections and to prevent infection after ocular surgery. Bacterial infections are and will remain contagious until treated for 24–48 hours.
Superinfection from a contaminated dropper
Unfortunately, the risk of superinfection is high when using ophthalmic antibiotics due to contamination of the eyedropper or tube. Counseling on the proper technique of administration is a critical teaching point to help reduce the risk of superinfection.
Erythromycin for newborns
In newborns born to someone with active disease, 1 cm of ointment is administered one time right after delivery to prevent eye infections, especially gonococcal ophthalmia neonatorum (GON) and chlamydial ophthalmia.
Harmless white precipitate with ciprofloxacin
During the first 7 days of treating a corneal ulcer with ciprofloxacin drops, a nonharmful white crystalline precipitate commonly forms on the corneal defect. This precipitate will resolve on its own and causes no corneal damage (DailyMed, Ciprofloxacin, 2022).
No trifluridine beyond 21 days
Continuous administration of trifluridine for periods exceeding 21 days should be avoided because of potential ocular toxicity.
Retinal detachment warning signs
The client taking an ocular antiviral should: Immediately notify the health care provider if they experience reduced vision, floaters, flashes of light, or a curtain-like shadow over their field of vision because these could be signs of retinal detachment.
Terms to know
- Hyphema
- Blood can enter the aqueous humor, resulting in a hyphema (a collection of blood in the anterior chamber of the eye).
- Natamycin
- The only FDA-approved drug for ocular fungal infections is natamycin (Natacyn).
- Trifluridine
- Trifluridine (Viroptic) is the most commonly administered antiviral ophthalmic drug.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client using ketorolac eye drops after cataract surgery for three weeks reports worsening eye pain, and the provider finds corneal epithelial breakdown. What should the nurse expect?
- Continue the drops and add artificial tears.
- Add latanoprost to speed healing.
- Double the dose to control inflammation.
- Stop the topical NSAID immediately and monitor corneal healing closely.
Answer: Stop the topical NSAID immediately and monitor corneal healing closely.
Clients with corneal epithelial breakdown should immediately stop topical NSAIDs and be closely monitored for corneal healing. Continuing or increasing the drug risks further damage, and NSAIDs reduce latanoprost's effect rather than helping healing.
A client has been using prednisolone eye drops for two weeks for uveitis. Which assessment is most important?
- Routine intraocular pressure checks
- Serum potassium level
- Hearing test
- Daily weight
Answer: Routine intraocular pressure checks
Extended use of ocular corticosteroids can raise IOP and lead to glaucoma, so anyone using them more than 10 days should have IOP checked routinely. The other assessments are not described for ocular steroids.
A parent asks whether their child with bacterial conjunctivitis who started antibiotic eye drops this morning can return to day care today. What should the nurse explain?
- The child is no longer contagious after the first dose.
- Bacterial eye infections remain contagious until treated for 24–48 hours.
- The child is contagious until the bottle is finished.
- Bacterial conjunctivitis is never contagious.
Answer: Bacterial eye infections remain contagious until treated for 24–48 hours.
Bacterial infections remain contagious until treated for 24–48 hours. The first dose does not end contagiousness, and there is no requirement to finish the bottle before the child is no longer contagious.
A client is prescribed trifluridine eye drops for herpes simplex keratitis. Which teaching points should the nurse include? Select all that apply.
- Store the medication in the refrigerator.
- Report floaters, flashes of light or a curtain-like shadow immediately.
- Once symptoms go away, the virus is gone for good.
- Let the drops reach room temperature before instilling them.
- Wash face, hands and any exposed skin after handling the drug.
Answer: Store the medication in the refrigerator., Report floaters, flashes of light or a curtain-like shadow immediately., Let the drops reach room temperature before instilling them., Wash face, hands and any exposed skin after handling the drug.
Trifluridine is refrigerated, instilled at room temperature, and handled with thorough washing; floaters, flashes or a curtain-like shadow may signal retinal detachment. Herpes lies dormant, so the client should not assume the organism is eliminated.
A client being treated for a corneal ulcer with ciprofloxacin eye drops is found on day 4 to have a white crystalline deposit on the corneal defect. How should the nurse interpret this?
- It is a sign of hypersensitivity; stop the drug.
- It means the ulcer is perforating.
- It is a fungal superinfection requiring an antifungal.
- It is a nonharmful precipitate that resolves on its own.
Answer: It is a nonharmful precipitate that resolves on its own.
During the first 7 days of ciprofloxacin treatment for a corneal ulcer, a nonharmful white crystalline precipitate commonly forms and resolves without corneal damage. It is not described as superinfection, hypersensitivity or perforation.
A client is going home with an ocular antibacterial. Which instructions are appropriate? Select all that apply.
- Keep driving even if vision is blurred.
- Wash off eye makeup and wash hands before each dose.
- Seek immediate care for severe eye redness or swelling of the lips or face.
- Do not wear contact lenses during the course of treatment.
- Let the dropper tip touch the eye to measure the dose.
Answer: Wash off eye makeup and wash hands before each dose., Seek immediate care for severe eye redness or swelling of the lips or face., Do not wear contact lenses during the course of treatment.
Clients should wash off makeup and hands, avoid contact lenses during treatment and seek care for hypersensitivity signs. Touching the eye with the dropper contaminates it and raises superinfection risk, and clients should not drive with blurred vision.
Where every quote comes from
Section 38.2 Ocular Anti-inflammatories and Anti-infectives of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.