Pharmacology · chapter 40 · Dermatologic Disorder Drugs
Introduction to the Skin and Its Function
The 13 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Three layers of the skin
The epidermis, the dermis, and the hypodermis are the layers that comprise the skin.
What the hypodermis does
The hypodermis is composed of fatty tissues and membranes that hold the dermis to the underlying muscle.
The dermis carries vessels and nerves
The dermis is rich in vascularity, nerves, and sensory receptors embedded in a more elastic, collagenous system of fibers.
The reticular layer
The bottom dermal sublayer—the reticular layer—is much thicker and more vascular than the other skin layers and contains more nerve and sensory functions.
The papillary layer
The uppermost sublayer—the papillary layer—contains papillae, which extend upward into the epidermis to hold the dermis and epidermis together. The papillary layer also contains phagocytes, which act to destroy bacteria that may penetrate the epidermis.
The epidermis has no vessels
Unlike the dermis, the epidermis does not contain blood vessels and nerves, but is composed mainly of cellular sublayers that protect the dermis.
Thicker skin on palms and soles
The stratum lucidum is an additional layer that provides a thicker layer of epidermis in areas that need more protection, such as the palms of the hands and soles of the feet.)
The basal layer
The basal layer is the only epidermal sublayer that is not made from keratin cells. This layer bonds to the dermis to connect it to epidermal tissues.
Langerhans cells protect
Encompassed in this layer are Langerhans cells, which eliminate foreign bacteria and wastes that enter the spinous layer, providing protection from invading organisms.
Skin cells turn over fast
Human skin has a high mitotic rate and has more rapid cell development and cell death than many other body tissues.
The cornified layer
The cornified layer is the outermost layer that forms the visible, external skin and is 20–30 cells thick (Yousef et al., 2022).
Broken skin lets organisms in
As skin integrity becomes compromised, bacteria, other organisms, and contaminating substances may enter the body through breaks in the skin. Dermatologic medications assist in healing breaks in the skin, preventing infection, and maintaining healthy skin.
Skin conditions look different on darker skin
Skin conditions in darker-skinned individuals often present differently than in lighter-skinned individuals.
Terms to know
- Hypodermis
- The foundation of the skin is known as the hypodermis (also subcutaneous tissue or superficial fascia).
- Epidermis
- The epidermis is the outermost layer of skin comprising the external skin surface of humans.
- Keratinocytes
- The remaining sublayers of the epidermis are composed of keratinocytes, cells that are protein based, giving rise to hair, nail, and skin cells that are strong and water-resistant.
- Stratum lucidum
- The stratum lucidum is an additional layer that provides a thicker layer of epidermis in areas that need more protection, such as the palms of the hands and soles of the feet.)
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client has a shallow scrape that involves only the epidermis. It is not bleeding. The client asks why. Which explanation is accurate?
- The epidermis does not contain blood vessels.
- The hypodermis stops all bleeding.
- The epidermis is the most vascular layer of the skin.
- Langerhans cells clot the blood.
Answer: The epidermis does not contain blood vessels.
Unlike the dermis, the epidermis has no blood vessels or nerves, so a wound limited to it does not bleed. The dermis, especially the reticular layer, is the vascular part, and Langerhans cells remove bacteria and wastes rather than clot blood.
A client has a laceration deep into the dermis and reports significant pain. Which statement explains this?
- The basal layer is made of keratin cells that sense pain.
- The reticular layer of the dermis is highly vascular and contains more nerve and sensory functions.
- The cornified layer contains most of the skin's nerves.
- The epidermis is the thickest nerve layer.
Answer: The reticular layer of the dermis is highly vascular and contains more nerve and sensory functions.
The reticular layer of the dermis is thicker and more vascular than other layers and contains more nerve and sensory function, so deep wounds hurt and bleed more. The outer epidermal layers have no nerves, and the basal layer is the one sublayer not made from keratin cells.
A nurse is caring for a client with a large area of broken skin. Why is this a priority concern?
- Bacteria and other substances can enter the body through breaks in the skin.
- Broken skin only affects appearance.
- Broken skin lowers the skin's mitotic rate permanently.
- Broken skin stops new skin cells from forming.
Answer: Bacteria and other substances can enter the body through breaks in the skin.
When skin integrity is compromised, bacteria, other organisms and contaminating substances can enter through the breaks, so infection prevention is a priority. The section describes skin as having a high mitotic rate, not a permanently lowered one.
Which skin structures or cells help protect the body from invading bacteria? Select all that apply.
- Phagocytes in the papillary layer
- Langerhans cells in the spinous layer
- The intact epidermis covering the dermis
- Blood vessels in the cornified layer
- Fat in the hypodermis that digests bacteria
Answer: Phagocytes in the papillary layer, Langerhans cells in the spinous layer, The intact epidermis covering the dermis
Phagocytes in the papillary layer destroy bacteria, Langerhans cells eliminate foreign bacteria in the spinous layer, and the epidermal sublayers protect the dermis. The hypodermis is fatty tissue that anchors the dermis, and the epidermis has no blood vessels.
A nurse is assessing a rash on a client with dark skin. Which principle should guide the assessment?
- Only the hypodermis should be assessed.
- Rashes do not occur on darker skin.
- Skin conditions in darker-skinned clients often present differently than in lighter-skinned clients.
- Skin conditions look the same on all skin tones.
Answer: Skin conditions in darker-skinned clients often present differently than in lighter-skinned clients.
Skin conditions in darker-skinned individuals often present differently, and this has been identified as a barrier to correct diagnosis and treatment. The other statements are not supported by the section.
A student is reviewing the dermis before a wound care lab. Which statements about the dermis are accurate? Select all that apply.
- It contains nerves and sensory receptors.
- It is rich in blood vessels.
- Its papillary layer helps hold the dermis and epidermis together.
- It is made only of dead keratin cells.
- It is the outermost visible layer of skin.
Answer: It contains nerves and sensory receptors., It is rich in blood vessels., Its papillary layer helps hold the dermis and epidermis together.
The dermis is rich in vascularity, nerves and sensory receptors, and its papillae extend into the epidermis to hold the layers together. The outermost visible layer is the cornified layer of the epidermis.
Where every quote comes from
Section 40.1 Introduction to the Skin and Its Function of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.