Pharmacology · chapter 40 · Dermatologic Disorder Drugs
Acne Drugs
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
What causes or worsens acne
Oily skin, hormonal changes, family history, and some medications may cause or exacerbate acne.
Treatment starts with hygiene
Effective treatment of acne begins with proper skin hygiene. In addition to cleansing and exfoliating the skin, treatment also focuses on reducing inflammation and decreasing bacteria on the skin.
Why oral anti-infectives are used
Systemic medications for the treatment of acne consist mainly of oral anti-infectives used to reduce bacterial colonization in skin pores.
Common adverse effects of systemic drugs
Common adverse effects associated with these treatments include hypersensitivity reactions, yeast infections, and gastrointestinal intolerance.
Tetracyclines, teeth and bones
Tetracyclines are also associated with skin rashes, tooth damage and discoloration, and altered bone growth and development.
Topical and systemic together
Topical acne medications are often used in combination with systemic acne medications to provide better management of acne.
How salicylic acid helps
Salicylic acid, another topical treatment, assists in acne treatment by exfoliating dead skin cells to reduce pore blockages, reducing inflammation, and decreasing sebum secretion.
Local effects of topical drugs
Adverse effects for topical acne medications most often involve localized skin redness, scaling, itching, and burning.
Avoid irritating soaps and cleansers
These may worsen when adapalene is used concomitantly with other substances that cause irritation or dry skin. For this reason, contraindications include the use of other non-approved substances, soaps, and cleansers that cause skin irritation.
No sun and no occlusive dressings
Other contraindications are sun or other ultraviolent light and the use of occlusive dressings—those that do not allow air or moisture to get in or out.
Adolescents stop treatment early
Adolescents using topical acne medications are at high risk of discontinuing treatment prematurely because of improved symptoms, side effects, and the need to use multiple products or treatments.
Assess the psychosocial impact
Evaluate and document the client’s response to current treatment and overall improvement of skin condition. Assess the psychosocial impact of acne on individual clients.
Thin layer, away from the eyes
Apply only a thin layer of medications to the affected areas only. Avoid contact with eyes and mucous membranes.
Pregnancy warning for systemic drugs
Embryo-fetal loss and malformations may occur when systemic acne drugs are administered to a pregnant client.
Terms to know
- Acne vulgaris
- Acne vulgaris (acne) is a skin condition in which sebum —dead skin cells—and bacteria accumulate in a skin pore.
- Occlusive dressings
- Other contraindications are sun or other ultraviolent light and the use of occlusive dressings—those that do not allow air or moisture to get in or out.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A provider is choosing an oral antibiotic for a 7-year-old with severe acne. The nurse questions an order for tetracycline. Why?
- Tetracyclines cause hypertension in children.
- Tetracyclines are only effective as a cream.
- Tetracyclines do not act on skin bacteria.
- Tetracyclines can damage and discolor teeth and alter bone growth.
Answer: Tetracyclines can damage and discolor teeth and alter bone growth.
Tetracyclines are associated with tooth damage and discoloration and altered bone growth, and tetracycline is contraindicated in children younger than 8 years. The other options are not supported by the section.
A client using adapalene gel asks whether she can keep using her alcohol-based toner and strong exfoliating soap. What should the nurse advise?
- Avoid them, because irritating or drying products can worsen redness, scaling and burning.
- Use them only on days she skips the gel.
- Apply the toner on top of the gel.
- Yes, drying products help the gel work faster.
Answer: Avoid them, because irritating or drying products can worsen redness, scaling and burning.
Local redness, scaling, itching and burning may worsen when adapalene is used with other irritating or drying substances, so irritating soaps and cleansers are contraindicated. Alternating or layering them does not remove the problem.
A nurse is teaching a teenager how to use a topical acne medication. Which instructions are correct? Select all that apply.
- Apply only a thin layer to the affected areas.
- Wash hands before and after application.
- Cover the treated areas with an occlusive dressing overnight.
- Cleanse the skin thoroughly before applying.
- Avoid contact with the eyes and mucous membranes.
Answer: Apply only a thin layer to the affected areas., Wash hands before and after application., Cleanse the skin thoroughly before applying., Avoid contact with the eyes and mucous membranes.
Clients cleanse the skin, apply a thin layer only to affected areas, avoid eyes and mucous membranes and wash hands before and after. Occlusive dressings are contraindicated with topical acne drugs.
A sexually active client is starting a systemic acne medication. Which teaching is essential?
- Stop the drug only after pregnancy is confirmed.
- Increase sun exposure to speed healing.
- Use birth control as instructed and avoid pregnancy.
- Pregnancy has no effect on acne treatment.
Answer: Use birth control as instructed and avoid pregnancy.
Systemic acne drugs can cause embryo-fetal loss and malformations, so clients use birth control as instructed and avoid pregnancy. Sun and UV light are contraindications for topical acne treatment, not a way to speed healing.
A 15-year-old stops using his acne cream because his skin looks better. Which factor does the section identify as increasing adherence in adolescents?
- Stopping treatment once symptoms improve
- Using occlusive dressings
- Anticipatory guidance about side effects
- Adding more products to the regimen
Answer: Anticipatory guidance about side effects
Adolescents often stop early because of improvement, side effects and multiple products; monotherapy, oral medications and anticipatory guidance on side effects can increase adherence. Adding products makes adherence harder.
A client is taking an oral antibiotic for acne. Which adverse effects should the nurse monitor for? Select all that apply.
- Hair growth on the palms
- Skin rashes
- Gastrointestinal intolerance
- Yeast infections
- Hypersensitivity reactions
Answer: Skin rashes, Gastrointestinal intolerance, Yeast infections, Hypersensitivity reactions
Systemic acne treatments commonly cause hypersensitivity reactions, yeast infections and gastrointestinal intolerance, and tetracyclines are also associated with skin rashes. Hair growth on the palms is not described.
Where every quote comes from
Section 40.2 Acne Drugs of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.