Pharmacology · chapter 18 · Antihypertensive and Antianginal Drugs
Calcium Channel Blockers
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
What calcium channel blockers do
Calcium channel blocker s are a classification of drug that blocks calcium from entering cells by binding to long-acting voltage-gated calcium channels in the heart, smooth muscle, and pancreas.
Vasodilation, slower rate, lower pressure
Calcium causes vasoconstriction. Calcium channel blockers inhibit calcium and allow for vasodilation, thereby causing the heart rate to slow and blood pressure to lower.
Uses and the two groups
Calcium channel blockers are commonly used to treat hypertension, angina, and arrhythmias. Calcium channel blockers are classified as dihydropyridines or nondihydropyridines.
Dihydropyridines
Dihydropyridines are peripheral vasodilators that lower blood pressure and heart rate; they are used to treat post-intracranial hemorrhage, vasospasm, and migraines.
Nondihydropyridines slow the heart
In addition to their action on the peripheral vasculature, nondihydropyridines inhibit the sinoatrial and AV nodes, slowing cardiac conduction and heart rate and decreasing oxygen demand.
Protein binding and formulations
They are highly protein bound, which increases the volume of distribution within the body. Calcium channel blockers are available in long- and short-acting formulas.
Effective in non-Hispanic Black adults
Calcium channel blockers are among the most effective antihypertensive classifications of drugs for use in non-Hispanic Black adults.
Common adverse effects
Adverse effects of calcium channel blockers include dizziness, constipation, palpitations, fatigue, flushing, nausea, rash, headache, and swelling in the legs and feet.
Serious side effects and hypersensitivity
Serious side effects include thrombocytopenia, hypotension, and hyperglycemia. Clients with a hypersensitivity to calcium channel blockers or their components should not use this classification of drug.
Other contraindications
Other contraindications include sick sinus syndrome (except in clients with an artificial pacemaker), severe hypotension, a history of myocardial infarction, or a history of pulmonary congestion.
St. John's wort and grapefruit juice
Monitor the client for interactions because many medications and herbal supplements, such as St. John’s wort, interact with calcium channel blockers. Grapefruit juice also can affect the action of certain calcium channel blockers.
Side effects to report
Report side effects such as severe headaches, dizziness, lightheadedness, flushing, nausea, and leg swelling to their health care provider.
Take with food
Take this medication with food to avoid GI upset, nausea, and vomiting.
Black box: immediate-release nifedipine
Immediate release nifedipine, a potent calcium blocker, may increase the risk of myocardial infarction, stroke, and arrhythmias.
Terms to know
- Calcium channel blocker
- Calcium channel blocker s are a classification of drug that blocks calcium from entering cells by binding to long-acting voltage-gated calcium channels in the heart, smooth muscle, and pancreas.
- Dihydropyridines
- Dihydropyridines are peripheral vasodilators that lower blood pressure and heart rate; they are used to treat post-intracranial hemorrhage, vasospasm, and migraines.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
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Every question here, with the answer
A client taking amlodipine for hypertension tells the nurse, "I feel much better, so I plan to stop my blood pressure pill today." What should the nurse explain?
- Stopping it will only cause mild constipation.
- Stopping a calcium channel blocker abruptly may cause chest pain, so talk to your provider first.
- You can stop it if you switch to grapefruit juice each morning.
- Stopping suddenly is safe once blood pressure is normal.
Answer: Stopping a calcium channel blocker abruptly may cause chest pain, so talk to your provider first.
The section warns that abrupt discontinuation of calcium channel blockers may cause chest pain, so the client should not stop the drug on their own. Grapefruit juice affects these drugs rather than replacing them, and constipation is an adverse effect of taking the drug, not of stopping it.
A client starting a calcium channel blocker asks how to prevent the stomach upset they had with the first dose. What should the nurse teach?
- Take the medication with food.
- Skip the dose on days you feel nauseated.
- Take the medication with grapefruit juice.
- Take the medication only at bedtime on an empty stomach.
Answer: Take the medication with food.
Client teaching says to take the medication with food to avoid GI upset, nausea, and vomiting. Grapefruit juice can affect the action of certain calcium channel blockers, and an empty stomach or skipping doses is not recommended.
A nurse is teaching a client who is taking a calcium channel blocker. Which side effects should the client report to the health care provider? Select all that apply.
- Leg swelling
- Severe headaches
- Flushing
- Improved exercise tolerance
- Lightheadedness
Answer: Leg swelling, Severe headaches, Flushing, Lightheadedness
The client should report severe headaches, dizziness, lightheadedness, flushing, nausea, and leg swelling. Improved exercise tolerance is not an adverse effect.
The nurse reviews the history of a client with a new prescription for a calcium channel blocker. Which findings are contraindications? Select all that apply.
- History of pulmonary congestion
- Stage 1 hypertension
- Sick sinus syndrome without an artificial pacemaker
- Severe hypotension
- History of myocardial infarction
Answer: History of pulmonary congestion, Sick sinus syndrome without an artificial pacemaker, Severe hypotension, History of myocardial infarction
Contraindications include sick sinus syndrome (unless the client has an artificial pacemaker), severe hypotension, and a history of myocardial infarction or pulmonary congestion. Hypertension is what the drug treats.
During a medication history, a client on diltiazem mentions taking an herbal supplement for mood. Which supplement should the nurse flag for a possible interaction?
- St. John's wort
- Food taken with each dose
- A daily multivitamin with no herbs
- Plain water with meals
Answer: St. John's wort
Many medications and herbal supplements, such as St. John's wort, interact with calcium channel blockers, so the nurse monitors for interactions. Taking the drug with food is recommended, not a concern.
A client asks why verapamil, a nondihydropyridine, is used to control their fast heart rate. Which explanation is accurate?
- It increases calcium entry into heart cells.
- It inhibits the SA and AV nodes, slowing conduction and heart rate.
- It speeds up conduction through the AV node.
- It works only on the blood vessels of the legs.
Answer: It inhibits the SA and AV nodes, slowing conduction and heart rate.
Nondihydropyridines inhibit the sinoatrial and AV nodes, slowing cardiac conduction and heart rate and decreasing oxygen demand. Calcium channel blockers block calcium from entering cells rather than increasing it, and they slow conduction rather than speeding it.
Where every quote comes from
Section 18.5 Calcium Channel Blockers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.