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Pharmacology · chapter 18 · Antihypertensive and Antianginal Drugs

Beta-Adrenergic Blockers

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. What beta blockers inhibit

    Beta-adrenergic blockers (beta blockers) are a classification of drugs that inhibit chronotropic, inotropic, and vasoconstrictor response to catecholamine—such as epinephrine and norepinephrine—by exerting effects on adrenergic receptors beta 1, beta 2, and alpha.
  2. Nonselective versus cardio-selective

    Nonselective beta blockers affect both beta 1 and beta 2 and act on the cardiovascular and respiratory systems. Cardio-selective beta blockers, in contrast, affect beta 1, which impacts the cardiovascular system (Tucker et al., 2022).
  3. Effects on the heart

    Beta blockers decrease heart rate, decrease myocardial contractility, and decrease the rate of conduction through the atrioventricular (AV) node, thereby lowering blood pressure and heart rate.
  4. Do not crush extended-release forms

    Extended-release beta blockers should not be crushed. Nurses should monitor blood pressure and pulse rate of clients using beta blockers.
  5. Hold for low pressure or slow pulse

    Beta blockers should not be administered if the client is hypotensive or has a heart rate of less than 60 (Farzam Jan, 2022).
  6. Masked low blood sugar

    Beta blockers may mask low blood sugar levels in clients with diabetes due to sympathetic nervous system inhibition.
  7. Asthma and chronic lung disease

    Asthmatic clients and clients with chronic lung diseases should be monitored carefully while taking beta blockers because lung function can decrease due to beta 2 inhibition.
  8. Serious adverse effects

    Serious adverse effects include bradycardia, arrhythmias, hypoglycemia, and hypotension. Rare side effects include sexual and erectile dysfunction.
  9. Contraindicated in moderate to severe asthma

    Beta blockers are contraindicated in clients with moderate to severe asthma and/or chronic lung diseases due to the potential for causing an exacerbation.
  10. Caution in diabetes

    People with diabetes should use beta blockers cautiously because they can mask the symptoms of hypoglycemia, causing confusion, fainting, or seizures.
  11. Interaction with short-acting beta agonists

    To prevent a pharmacological drug interaction, the nurse must assess whether clients are taking short-acting beta agonists (SABAs) because beta blockers can reduce their effectiveness.
  12. Heart rate under 60

    Do not administer the drug if the client’s heart rate is less than 60 beats per minute and notify the health care provider.
  13. Do not mix with these supplements

    The client taking a beta-adrenergic blocker should not: Take beta-adrenergic blockers with over-the-counter (OTC) drugs or herbal supplements such as ma-huang, ephedra, black cohosh, hawthorn, or licorice without consulting their health care provider because these supplements may interfere with the action of the beta-adrenergic blocker.
  14. Black box warning: taper, never stop abruptly

    Beta blocker therapy should not be abruptly stopped but gradually tapered to avoid exacerbation of angina and myocardial infarction.

Terms to know

Beta-adrenergic blockers
Beta-adrenergic blockers (beta blockers) are a classification of drugs that inhibit chronotropic, inotropic, and vasoconstrictor response to catecholamine—such as epinephrine and norepinephrine—by exerting effects on adrenergic receptors beta 1, beta 2, and alpha.
Nonselective beta blockers
Nonselective beta blockers affect both beta 1 and beta 2 and act on the cardiovascular and respiratory systems.
Cardio-selective beta blockers
Cardio-selective beta blockers, in contrast, affect beta 1, which impacts the cardiovascular system (Tucker et al., 2022).
Off-label
The health care provider may prescribe beta blockers off-label (against FDA-approved labeling indications for drug use) for anxiety.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

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Every question here, with the answer

  1. Before giving a scheduled dose of atenolol, the nurse finds a heart rate of 54 beats per minute and a blood pressure of 118/76 mm Hg. What should the nurse do?

    1. Give the dose as scheduled.
    2. Give the dose with a glass of water to speed absorption.
    3. Give the dose and recheck the pulse in four hours.
    4. Hold the dose and notify the health care provider.

    Answer: Hold the dose and notify the health care provider.

    The nurse does not give a beta blocker when the heart rate is less than 60 beats per minute and notifies the provider. Giving the dose in any form would slow an already slow heart further.

  2. A client with asthma uses an albuterol inhaler as needed. The provider is considering a beta blocker for hypertension. Why should the nurse raise this with the provider?

    1. Albuterol must be stopped before any beta blocker is started.
    2. Beta blockers make albuterol work too strongly.
    3. Beta blockers can reduce the effectiveness of short-acting beta agonists.
    4. Beta blockers cure the client's asthma.

    Answer: Beta blockers can reduce the effectiveness of short-acting beta agonists.

    The nurse must assess whether clients take short-acting beta agonists because beta blockers can reduce their effectiveness, and beta 2 inhibition can decrease lung function. The other options are not supported by the section.

  3. A client with type 1 diabetes has just started metoprolol. What should the nurse teach about low blood sugar?

    1. You no longer need to check your glucose.
    2. Metoprolol prevents low blood sugar.
    3. Stop metoprolol if your glucose is low.
    4. Your usual symptoms of low blood sugar may be masked, so check your glucose closely.

    Answer: Your usual symptoms of low blood sugar may be masked, so check your glucose closely.

    Beta blockers can mask the symptoms of hypoglycemia in clients with diabetes, so glucose must be monitored closely. They do not prevent hypoglycemia, and stopping the drug without the provider is unsafe.

  4. A client taking propranolol says, "I feel fine now, so I'm going to stop my pills this weekend." What is the nurse's best response?

    1. That is fine once your blood pressure is normal.
    2. Stop every other dose first, then stop completely.
    3. Switch to an herbal supplement instead.
    4. Do not stop suddenly; talk with your provider, because stopping abruptly can worsen angina or cause a heart attack.

    Answer: Do not stop suddenly; talk with your provider, because stopping abruptly can worsen angina or cause a heart attack.

    The black box warning says beta blocker therapy should not be stopped abruptly but tapered gradually to avoid exacerbation of angina and myocardial infarction, and clients should seek the provider's advice first. A self-made taper or herbal substitute is not safe.

  5. A nurse is teaching a client who is going home on a beta-adrenergic blocker. Which instructions should the nurse include? Select all that apply.

    1. Ask your provider before taking herbal supplements such as ephedra or licorice.
    2. Report weight gain and swelling in your legs.
    3. Take the medication only when your heart feels fast.
    4. Check your pulse before taking the medication.
    5. Do not crush extended-release tablets.

    Answer: Ask your provider before taking herbal supplements such as ephedra or licorice., Report weight gain and swelling in your legs., Check your pulse before taking the medication., Do not crush extended-release tablets.

    Clients check their pulse before each dose, do not crush extended-release forms, report signs of worsening heart failure such as weight gain and peripheral edema, and consult the provider before herbal supplements. Taking the drug only when the heart feels fast is intermittent use, which is unsafe.

  6. Which serious adverse effects should the nurse monitor for in a client taking a beta blocker? Select all that apply.

    1. Hypotension
    2. Hypoglycemia
    3. Bradycardia
    4. Hypertension
    5. Hyperkalemia

    Answer: Hypotension, Hypoglycemia, Bradycardia

    The serious adverse effects of beta blockers listed in the section are bradycardia, arrhythmias, hypoglycemia, and hypotension. Beta blockers lower blood pressure rather than raise it, and hyperkalemia is not listed for beta blockers here.

Where every quote comes from

Section 18.4 Beta-Adrenergic Blockers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.