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Pharmacology · chapter 6 · Introduction to the Immune System and the Inflammatory Response

Vaccine-Preventable Diseases, Vaccines, and Immunizations

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. What a vaccine contains

    Vaccines are biological preparations containing weakened or inactivated pathogens or their components, prompting the body to produce protective antibodies and memory cells.
  2. Acquired immunity lasts

    This type of immunity is long lasting and involves the production of memory B cells, which “remember” the encountered antigen and can mount a faster and stronger response upon subsequent exposures (Grubbs Kahwaji, 2022).
  3. Vaccination is artificially acquired active immunity

    Artificially acquired active immunity: This type of immunity is induced through vaccination.
  4. Passive immunity is short-lived

    Unlike active immunity, passive immunity does not involve the production of memory B cells, and the protection is short-lived.
  5. Natural passive immunity in newborns

    Passive immunity can be acquired through two main ways: Natural passive immunity: This occurs when antibodies are passed from a pregnant person to the fetus through the placenta during pregnancy or through breast milk during breastfeeding.
  6. Live attenuated vaccines

    These weakened strains can still replicate within the body but are rendered less virulent, so they do not cause the disease in healthy individuals. Examples of live attenuated vaccines include the measles, mumps, rubella (MMR) vaccine and the oral polio vaccine (OPV).
  7. Inactivated vaccines need boosters

    Inactivated vaccines often require multiple doses or booster shots to build and maintain immunity. Examples of inactivated vaccines include the hepatitis A vaccine and the injectable polio vaccine (IPV).
  8. How mRNA vaccines work

    Instead, mRNA vaccines contain genetic instructions (mRNA) that instruct the cells in the body to produce a specific viral or bacterial protein.
  9. Herd immunity threshold for measles

    For highly contagious infections like measles, a large proportion (around 95%) of the population needs to be immune to prevent outbreaks.
  10. Vaccine hesitancy

    It is driven by factors like safety concerns, distrust in vaccines or health care providers, and misinformation. Vaccine hesitancy poses a public health challenge, as it can lead to outbreaks of preventable diseases.
  11. Reading a titer

    A positive titer indicates protective antibodies are present in the body, and the client is considered immune. If the titer is negative or below the protective level, a booster dose of the vaccine may be recommended to enhance immunity.
  12. Common local and systemic reactions

    Local reactions including tenderness, erythema, induration, and swelling at injection site. Systemic reactions include fever, irritability, drowsiness, anorexia, and vomiting.
  13. Serious reactions and contraindications

    Other reactions include anaphylactic reactions, such as urticaria and angioedema, as well as nervous system reactions such as convulsions and syncope. Contraindications to vaccines include hypersensitivity to the vaccine or any of its constituents.
  14. Check storage and expiration

    Check the vaccine’s storage and handling to verify that the vaccine has been stored at the appropriate temperature and that it is within the expiration date to maintain its potency and efficacy.

Terms to know

Immunity
Immunity Immunity is the ability of an organism to resist or defend against harmful pathogens such as microorganisms or toxic substances (CDC, 2023a).
Passive immunity
Passive Immunity Passive immunity is the temporary protection against a specific pathogen that is conferred to a client by receiving pre-formed antibodies rather than producing them internally (Slifka Amanna, 2018).
Immunization
Immunization is the process of administering vaccines to clients, aiming to establish immunity against certain diseases (CDC, 2023a).
Herd immunity
Herd immunity is a state where a significant portion of a population becomes immune to a specific infectious disease through vaccination or previous exposure (McDermott, 2021).
titer
A titer is a blood test that measures the level of antibodies against the virus in the bloodstream.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A nursing student's hepatitis B titer comes back below the protective level after completing the vaccine series. What does the nurse expect?

    1. The student needs passive immunity for life.
    2. The titer should be ignored because the series is complete.
    3. The student is considered immune.
    4. A booster dose of the vaccine may be recommended.

    Answer: A booster dose of the vaccine may be recommended.

    A titer negative or below the protective level means immunity may be insufficient, so a booster may be recommended. A positive titer, not a low one, indicates immunity, and the other options are not supported by the section.

  2. A new mother asks why her breastfed infant is protected from some infections before receiving all vaccines. Which response is accurate?

    1. Breast milk makes the infant produce memory B cells.
    2. Antibodies passed through breast milk give temporary natural passive immunity.
    3. Breastfeeding gives lifelong immunity.
    4. The infant has artificially acquired active immunity.

    Answer: Antibodies passed through breast milk give temporary natural passive immunity.

    Antibodies passed through the placenta or breast milk give natural passive immunity, which is temporary and does not create memory B cells. Artificially acquired active immunity comes from vaccination.

  3. A client asks why the injectable polio vaccine requires several doses. Which explanation is correct?

    1. It gives only passive immunity.
    2. Inactivated vaccines often need multiple doses or boosters to build and maintain immunity.
    3. It contains mRNA that fades quickly.
    4. It is a live vaccine that can cause polio if given once.

    Answer: Inactivated vaccines often need multiple doses or boosters to build and maintain immunity.

    The injectable polio vaccine is an inactivated vaccine, and inactivated vaccines often require multiple doses or boosters. It is not live, not mRNA, and it produces active, not passive, immunity.

  4. Before giving a vaccine, which actions should the nurse take? Select all that apply.

    1. Keep multi-dose vials in the immediate client treatment area.
    2. Draw up the vaccine next to the area for contaminated items.
    3. Confirm informed consent from the client or legal guardian.
    4. Verify storage temperature and expiration date.
    5. Review the medical history and immunization record for allergies.

    Answer: Confirm informed consent from the client or legal guardian., Verify storage temperature and expiration date., Review the medical history and immunization record for allergies.

    The nurse reviews history and records for contraindications, confirms informed consent and checks storage and expiration. Vaccines are drawn up in a clean area not next to contaminated items, and multi-dose vials are not kept in the immediate treatment area.

  5. A client asks which reactions after a vaccine should be reported to the health care provider. Which reactions should the nurse include? Select all that apply.

    1. Swelling at the injection site
    2. Fever
    3. Hair loss
    4. Urticaria
    5. Convulsions

    Answer: Swelling at the injection site, Fever, Urticaria, Convulsions

    The client should report local reactions such as swelling, systemic reactions such as fever, anaphylactic reactions such as urticaria and CNS reactions such as convulsions. Hair loss is not listed as a vaccine reaction in the section.

  6. Which finding in a client's history is a contraindication to giving a vaccine?

    1. Previous hypersensitivity to a component of the vaccine
    2. Planned international travel
    3. Age over 50 years
    4. Mild tenderness after a previous vaccine

    Answer: Previous hypersensitivity to a component of the vaccine

    Contraindications to vaccines include hypersensitivity to the vaccine or any of its constituents. Travel is a reason to update vaccines, mild tenderness is a common local reaction, and age alone is not listed as a contraindication.

Where every quote comes from

Section 6.2 Vaccine-Preventable Diseases, Vaccines, and Immunizations of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.