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Pharmacology · chapter 22 · Cardiac Emergency and Shock Drugs

Shock Drugs

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. What shock does to tissues

    Shock is a state of medical emergency in which tissues are not receiving enough oxygenated blood to sustain life. If not treated rapidly, decreased perfusion will cause hypoxia and eventually cell and tissue death.
  2. Epinephrine comes first in anaphylaxis

    Epinephrine, a nonselective adrenergic agonist, is the most important drug used to treat anaphylactic shock. It causes sympathetic nervous system stimulation, which dilates the pulmonary bronchioles to open up airways and constricts blood vessels to increase blood pressure.
  3. How fast epinephrine works

    Epinephrine acts very quickly and can decrease bronchoconstriction within 3–5 minutes. Epinephrine can be administered intramuscularly or intravenously depending on the acuteness of the situation.
  4. Albuterol as a second step

    Albuterol may be used in anaphylaxis if epinephrine does not fully open the airways. In anaphylaxis, it is administered as an inhaled nebulizer treatment.
  5. Albuterol adverse effects

    Albuterol can cause paradoxical bronchospasm, tachycardia, and an immediate hypersensitivity reaction. Hypersensitivity is the only contraindication to albuterol.
  6. Using the nebulizer

    Hold the nebulizer mouthpiece between their teeth with their lips closed around it. Hold the nebulizer in an upright position.
  7. Why fluids are needed in anaphylaxis

    Anaphylactic shock causes fluids to shift from within the blood vessels (intravascular) to the tissues (extravascular). This can occur very rapidly and is the primary cause of the shock.
  8. Fluid bolus in anaphylactic shock

    In anaphylactic shock, 1–2 L of an isotonic IV solution such as normal saline should be administered rapidly (at the highest flow rate possible) as soon as an IV is established.
  9. Fix the cause of hypovolemia first

    The first priority in hypovolemic shock is to correct the underlying cause; for example, if the hypovolemia is caused by blood loss, measures should be taken to stop the blood loss, and the client should receive a blood transfusion as soon as possible.
  10. Fluid bolus in hypovolemic shock

    In hypovolemic shock, 2 L of an isotonic IV solution should be administered as quickly as possible. After the initial fluid bolus, additional IV solution may be ordered to maintain blood pressure.
  11. Drugs for cardiogenic shock

    Cardiac output must be increased in order to restore adequate tissue perfusion. Medications used in cardiogenic shock include dopamine, dobutamine, and norepinephrine.
  12. Norepinephrine adverse effects

    Norepinephrine can cause cardiac arrhythmias, severe peripheral ischemia in clients who are hypovolemic, gangrene in clients with occlusive or thrombotic vascular disease (in high doses), and rebound hypotension after discontinuation.
  13. Norepinephrine and blood glucose

    Norepinephrine may cause decreased sensitivity to insulin, so clients with diabetes may need their glucose levels monitored more frequently as well as increased doses of antidiabetic medications.
  14. Norepinephrine extravasation

    Extravasation of norepinephrine at the IV site can cause tissue necrosis. There are no contraindications for norepinephrine.

Terms to know

Anaphylactic shock
Anaphylactic shock is a severe and life-threatening response to an allergen to which the body has a hypersensitivity.
Isotonic IV solutions
Isotonic IV solutions have the same amount of sodium concentration as blood does.
Hypovolemic shock
Hypovolemic shock occurs when the circulating volume of fluid has decreased so much that it affects tissue perfusion.
Cardiogenic shock
Cardiogenic shock occurs when the myocardium is not able to pump effectively enough to maintain cardiac output.
vasopressors
The use of vasopressors (drugs that increase blood pressure) in hypovolemic shock is controversial and will not be included in this section.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client develops hives, wheezing, and a blood pressure of 74/40 minutes after receiving an IV antibiotic. Which drug is the priority?

    1. Albuterol by nebulizer
    2. Dobutamine
    3. Epinephrine
    4. Norepinephrine

    Answer: Epinephrine

    Epinephrine is the most important drug for anaphylactic shock: it opens the airways and constricts blood vessels to raise blood pressure. Albuterol is added only if epinephrine does not fully open the airways, and the other drugs are used for cardiogenic shock.

  2. A trauma client is in hypovolemic shock from active bleeding. What is the first priority?

    1. Give albuterol by nebulizer.
    2. Start a norepinephrine infusion.
    3. Start dobutamine to increase contractility.
    4. Stop the blood loss and give a blood transfusion as soon as possible.

    Answer: Stop the blood loss and give a blood transfusion as soon as possible.

    The first priority in hypovolemic shock is correcting the underlying cause, which means stopping the bleeding and transfusing. Vasopressors in hypovolemic shock are controversial, and hypovolemia must be corrected before norepinephrine.

  3. A client with anaphylaxis is receiving albuterol by nebulizer. Which instructions should the nurse give? Select all that apply.

    1. Keep the nebulizer upright.
    2. Tilt the nebulizer on its side to breathe more easily.
    3. Tell the nurse if you feel chest pain or a racing heart.
    4. Expect the treatment to last about 10–15 minutes.
    5. Hold the mouthpiece between your teeth with your lips closed around it.

    Answer: Keep the nebulizer upright., Tell the nurse if you feel chest pain or a racing heart., Expect the treatment to last about 10–15 minutes., Hold the mouthpiece between your teeth with your lips closed around it.

    The client holds the mouthpiece between the teeth with lips closed, keeps the nebulizer upright, expects 10–15 minutes, and reports chest pain or rapid heart rate. Tilting the nebulizer contradicts the upright position.

  4. A client with type 2 diabetes is on a norepinephrine infusion for shock. Which assessment should the nurse increase?

    1. Visual acuity checks
    2. Blood glucose checks
    3. Stool guaiac tests
    4. Hearing checks

    Answer: Blood glucose checks

    Norepinephrine may decrease sensitivity to insulin, so clients with diabetes may need more frequent glucose monitoring and higher antidiabetic doses. The other assessments are not linked to norepinephrine in the section.

  5. A nurse is caring for a client receiving norepinephrine. Which actions are appropriate? Select all that apply.

    1. Correct hypovolemia before starting the infusion.
    2. Ignore mild pain at the IV site.
    3. Assess the IV site frequently.
    4. Stop the infusion abruptly once blood pressure is normal.
    5. Place the client on continuous cardiac monitoring.

    Answer: Correct hypovolemia before starting the infusion., Assess the IV site frequently., Place the client on continuous cardiac monitoring.

    Extravasation can cause tissue necrosis, hypovolemia must be corrected first, and cardiac monitoring is required because of arrhythmias. Abrupt discontinuation risks rebound hypotension, and IV site pain must be reported.

  6. A client in anaphylactic shock has just had an IV line placed. What fluid order should the nurse expect?

    1. 1–2 L of an isotonic solution such as normal saline given rapidly
    2. Oral fluids only
    3. A slow infusion of dextrose to keep the vein open
    4. Fluid restriction to prevent pulmonary edema

    Answer: 1–2 L of an isotonic solution such as normal saline given rapidly

    In anaphylactic shock fluid shifts out of the vessels, so 1–2 L of isotonic solution such as normal saline is given rapidly as soon as an IV is established. Slow, restricted, or oral fluids will not restore intravascular volume.

Where every quote comes from

Section 22.3 Shock Drugs of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.