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Pharmacology · chapter 34 · Diuretic Drugs

Potassium-Sparing Diuretics

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. Used with other diuretics

    These drugs are commonly used in combination with other diuretics to modify potassium losses.
  2. Potassium is kept, not lost

    In contrast to the actions of other diuretics, when the potassium-sparing drugs inhibit sodium reabsorption in this area of the nephron, potassium excretion is decreased, thus preserving serum potassium levels.
  3. Weak and slow to start

    The diuretic action of potassium-sparing diuretics is weaker than in other diuretic types, and the onset of action is delayed by as much as 3 days; however, the drugs are often used in combination with more potent diuretics to prevent or treat hypokalemia, heart failure, and hypertension.
  4. Spironolactone blocks aldosterone receptors

    Spironolactone is a potassium-sparing diuretic that competes with the aldosterone (mineralocorticoid) receptors in the distal tubule and collecting duct of the nephron.
  5. Spironolactone in resistant hypertension

    Spironolactone is often added as the fourth drug to treat resistant hypertension, which is defined as failure to reach blood pressure target levels when the client is receiving adequate doses of three antihypertensive drugs.
  6. Triamterene and magnesium

    Triamterene is a potassium-sparing diuretic that also increases the excretion of magnesium.
  7. Adverse effects of the class

    Adverse effects related to the diuretic action of these drugs include hyperkalemia, hyponatremia, and hyperuricemia, as well as renal tubular necrosis, glucose intolerance, and metabolic acidosis.
  8. Endocrine effects of spironolactone

    Endocrine effects of spironolactone therapy include gynecomastia (enlarged breasts), decreased libido, and other feminizing effects in male clients and menstrual alterations in female clients.
  9. Contraindications and cautions

    Contraindications include anuria, hyperkalemia, and renal insufficiency. These medications should be used with caution in older adults and individuals who have diabetes or gout.
  10. Hyperkalemia can stop the heart

    Clients taking potassium-sparing diuretics are accordingly at risk for hyperkalemia and its associated adverse effects. Hyperkalemia can cause arrhythmias and cardiac arrest if untreated.
  11. Weight gain that signals fluid retention

    Monitor the client’s weight for any significant increases (2 pounds in one day or 5 pounds in 1 week), which could indicate fluid retention.
  12. Watch salt substitutes and bananas

    Clients should be cautioned about consuming salt substitutes, bananas, and other potassium-rich foods when taking potassium-sparing diuretics. Clients often associate “water pills” with the need for additional dietary potassium.
  13. Avoid NSAIDs without asking

    From the book’s list of what the client should not do:

    Take nonsteroid anti-inflammatory medications without consulting their health care provider because these can increase potassium levels.
  14. Amiloride boxed warning

    Amiloride, a potassium-sparing diuretic, may cause hyperkalemia, either alone or when combined with hydrochlorothiazide and ACE inhibitors.

Terms to know

Resistant hypertension
Spironolactone is often added as the fourth drug to treat resistant hypertension, which is defined as failure to reach blood pressure target levels when the client is receiving adequate doses of three antihypertensive drugs.
Hirsutism
The drug is used off-label as part of gender-affirming hormone therapy and to treat hirsutism (excessive hair growth in a male growth pattern) and acne.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client taking spironolactone says, "My water pill makes me lose potassium, so I use a salt substitute and eat extra bananas." What is the nurse's best response?

    1. "That is a good way to replace lost potassium."
    2. "Salt substitutes are fine, but avoid bananas."
    3. "Eat bananas but only with the dose."
    4. "This drug keeps potassium in your body, so salt substitutes and extra potassium-rich foods can raise your potassium too high."

    Answer: "This drug keeps potassium in your body, so salt substitutes and extra potassium-rich foods can raise your potassium too high."

    Potassium-sparing diuretics decrease potassium excretion, so clients are cautioned about salt substitutes, bananas and other potassium-rich foods. Clients often wrongly link all water pills with a need for extra potassium.

  2. Which laboratory result is the priority for a client taking a potassium-sparing diuretic?

    1. Hemoglobin
    2. Serum albumin
    3. Serum potassium
    4. Platelet count

    Answer: Serum potassium

    Clients taking potassium-sparing diuretics are at risk for hyperkalemia, which can cause arrhythmias and cardiac arrest if untreated. The other labs are not the main concern named in the section.

  3. A male client has taken spironolactone for several months. Which findings should the nurse recognise as possible endocrine effects of the drug? Select all that apply.

    1. Enlarged breasts
    2. Other feminizing effects
    3. Increased muscle mass
    4. Hair loss on the scalp
    5. Decreased libido

    Answer: Enlarged breasts, Other feminizing effects, Decreased libido

    Spironolactone can cause gynecomastia, decreased libido and other feminizing effects in male clients. Hair loss and increased muscle mass are not listed.

  4. A client just started a potassium-sparing diuretic and on day 2 says it "isn't working." What should the nurse explain?

    1. The onset of action can be delayed by as much as 3 days.
    2. The drug only works when taken with bananas.
    3. The drug should be stopped because it is ineffective.
    4. The dose should be doubled right away.

    Answer: The onset of action can be delayed by as much as 3 days.

    Potassium-sparing diuretics have a weaker action, and onset can be delayed by as much as 3 days. Stopping or doubling the dose without the provider is not supported.

  5. In which clients is a potassium-sparing diuretic contraindicated or used with caution? Select all that apply.

    1. A client with renal insufficiency
    2. A client with hyperkalemia
    3. An older adult client with diabetes
    4. A client with hypokalemia from a loop diuretic
    5. A client with anuria

    Answer: A client with renal insufficiency, A client with hyperkalemia, An older adult client with diabetes, A client with anuria

    Contraindications include anuria, hyperkalemia and renal insufficiency, and caution is needed in older adults and clients with diabetes or gout. Hypokalemia from loop diuretics is a reason these drugs are used.

  6. A client taking a potassium-sparing diuretic asks about taking an over-the-counter anti-inflammatory for back pain. What should the nurse say?

    1. "Stop your diuretic while you take it."
    2. "Take it with a potassium supplement."
    3. "Check with your health care provider first, because these can increase potassium levels."
    4. "Any anti-inflammatory is safe with this drug."

    Answer: "Check with your health care provider first, because these can increase potassium levels."

    Clients taking potassium-sparing diuretics should not take NSAIDs without consulting the provider because they can increase potassium levels. Adding potassium or stopping the diuretic on their own is not advised.

Where every quote comes from

Section 34.4 Potassium-Sparing Diuretics of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.