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Pharmacology · chapter 39 · Otic Drugs

Otic Anti-inflammatories and Anti-infectives

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. When otic anti-inflammatories are used

    Otic anti-inflammatories are used for the treatment of superficial bacterial infections of the external auditory canal (i.e., otitis externa) caused by susceptible organisms. Anti-inflammatory medications frequently are administered in combination with antibiotics.
  2. Expect a response in 48–72 hours

    A treatment response should occur within 48–72 hours, otherwise the provider should reassess (Medina-Blasini Sharman, 2023).
  3. Anaphylaxis and latex droppers

    Rarely, anaphylaxis can occur with the first dose. Clients with latex allergies may need to use an alternative (latex-free) dropper for administration.
  4. Have someone present for the first dose

    If this is the first time using these drugs, administer with another person present for assistance in case a serious allergic reaction occurs.
  5. Warm the drops in the hands

    Roll the bottle of otic drops between their hands for a few moments to warm the drops. Instillation of cold drops can cause dizziness.
  6. Keep the ear facing up

    Keep the ear facing up for about 5 minutes for the drop(s) to bathe the ear canal and minimize the amount of medication leakage (Mayo Clinic, 2023).
  7. Do not overheat the drops

    The client taking an otic anti-inflammatory should not: Heat the drops above body temperature because administering drops that are too warm can damage the ear canal.
  8. Anti-infectives do not treat viruses

    Topical anti-infectives are prescribed to treat bacterial infections but are ineffective for viral infections.
  9. No improvement after one week

    If the infection does not improve after 1 week of treatment, cultures and susceptibility tests should be repeated to verify the identity of the organism and to determine whether the therapy should be changed.
  10. Watch for quinolone hypersensitivity

    Recognize and monitor for serious and potential side effects, primarily a rash or any evidence of hypersensitivity to quinolones. Anaphylaxis can occur.
  11. First-line and second-line for otitis media

    High-dose amoxicillin is the first-line choice for both children and adults (Danishyar Ashurst, 2023). If high-dose amoxicillin is not effective, high-dose amoxicillin-clavulanate is the second-line treatment.
  12. Diarrhea and C. difficile

    Systemic antibiotics can lead to diarrhea and possibly pseudomembranous colitis and Clostridium difficile infection.
  13. Late antibiotic-related diarrhea

    Antibiotic-related diarrhea can occur up to 2 months after ceasing antibiotic therapy.
  14. Augmentin strengths are not interchangeable

    Different forms of Augmentin contain different amounts of amoxicillin but the same amounts of clavulanic acid, so the strengths are not interchangeable. For example, two 250 mg Augmentin tablets are not the equivalent of a 500 mg tablet.

Terms to know

Anti-inflammatory drugs
Anti-inflammatory drugs block substances in the body that cause inflammation.
Otic anti-infectives
Otic anti-infectives are indicated for clients who have otitis externa.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

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Every question here, with the answer

  1. A client prescribed amoxicillin-clavulanate 500 mg has only 250 mg tablets at home and plans to take two. What should the nurse teach?

    1. The client must take the 500 mg tablet, because the strengths are not interchangeable.
    2. Crush the two tablets together.
    3. Take one 250 mg tablet twice as often.
    4. Two 250 mg tablets equal one 500 mg tablet, so this is fine.

    Answer: The client must take the 500 mg tablet, because the strengths are not interchangeable.

    Different forms of Augmentin contain different amounts of amoxicillin but the same amount of clavulanic acid, so two 250 mg tablets are not equivalent to one 500 mg tablet. Changing frequency or crushing does not fix the mismatch.

  2. A client using otic drops for otitis externa reports dizziness right after each dose. Which teaching point is most relevant?

    1. Warm the bottle by rolling it between the hands before instilling.
    2. Stop the drops and use cotton swabs instead.
    3. Keep the bottle in the refrigerator.
    4. Heat the drops in hot water above body temperature.

    Answer: Warm the bottle by rolling it between the hands before instilling.

    Cold drops can cause dizziness, so the bottle is rolled between the hands to warm it. Refrigerated drops would be cold, overheating can damage the ear canal, and cotton swabs risk perforation.

  3. A nurse is teaching a client how to use ciprofloxacin-hydrocortisone ear drops at home. Which instructions are correct? Select all that apply.

    1. Clean the canal with cotton swabs after each dose.
    2. Keep the ear facing up for about 5 minutes after the drops.
    3. Avoid driving until any dizziness has subsided.
    4. Wash hands before handling the bottle.
    5. Report ear pain or worsening itching.

    Answer: Keep the ear facing up for about 5 minutes after the drops., Avoid driving until any dizziness has subsided., Wash hands before handling the bottle., Report ear pain or worsening itching.

    Clients wash hands, keep the ear up for about 5 minutes, report pain or worsening itching (possible superinfection) and avoid driving while dizzy. Cotton swabs are avoided because of the risk of perforation.

  4. A client using an otic anti-inflammatory/antibiotic combination for otitis externa has no improvement after 72 hours. What should happen next?

    1. Continue the same drops for another month.
    2. Double the number of drops.
    3. Stop treatment because the infection will clear on its own.
    4. The provider should reassess the client.

    Answer: The provider should reassess the client.

    A treatment response should occur within 48–72 hours; otherwise the provider should reassess. Extending, doubling or stopping without reassessment is not supported, and prolonged use risks superinfection.

  5. A client with a latex allergy is starting otic drops for the first time. Which action is most appropriate?

    1. Skip hand hygiene to avoid skin irritation.
    2. Use the standard dropper since the drops do not contain latex.
    3. Use a latex-free dropper and have another person present for the first dose.
    4. Give the first dose at bedtime while the client is alone.

    Answer: Use a latex-free dropper and have another person present for the first dose.

    Clients with latex allergies should use a latex-free dropper, and the first dose is given with another person present in case of a serious allergic reaction. Being alone, using the standard dropper or skipping hand hygiene are unsafe.

  6. A child is being treated with amoxicillin for acute otitis media. Which instructions should the nurse give the parent? Select all that apply.

    1. Give all of the antibiotic as prescribed.
    2. Keep follow-up appointments.
    3. Report episodes of diarrhea to the health care provider.
    4. Diarrhea can still appear up to 2 months after the antibiotic ends.
    5. Share leftover antibiotic with a sibling who has ear pain.

    Answer: Give all of the antibiotic as prescribed., Keep follow-up appointments., Report episodes of diarrhea to the health care provider., Diarrhea can still appear up to 2 months after the antibiotic ends.

    Systemic antibiotics can cause diarrhea, including C. difficile, even up to 2 months after therapy, so diarrhea is reported; the full course is taken and follow-up kept. Antibiotics should never be shared.

Where every quote comes from

Section 39.2 Otic Anti-inflammatories and Anti-infectives of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.