Pharmacology · chapter 40 · Dermatologic Disorder Drugs
Other Dermatologic Condition Drugs and Topical Anti-infectives for Burns
The 13 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
How cantharidin removes warts
As a vesicant, cantharidin causes local tissue necrosis on those surfaces to which it is applied. This necrosis will eventually result in the sloughing of the wart and elimination of the virus.
Eczema is a systemic disease
Unlike conditions characterized solely by local irritation, atopic dermatitis is a systemic disease that has genetic predispositions, involves the immune system, and also has environmental influences.
Causes of contact dermatitis
Substances that may cause contact dermatitis include, but are not limited to, soaps, cosmetics, jewelry, and poison ivy/oak.
Who gets impetigo and why
Typically, impetigo is seen in infants and children, although it may occasionally be seen in adults. The causative organisms are most often Staphylococcus aureus and Streptococcus pyogenes bacteria.
Metronidazole and alcohol
When alcoholic beverages are mixed with metronidazole, a life-threatening disulfiram-like reaction may occur, resulting in palpitations, diaphoresis, flushing, nausea, and tachycardia (Stokes Abdijadid, 2019).
Sulfa allergy and sodium sulfacetamide
Sodium sulfacetamide, another treatment for rosacea, is antibacterial in function and is used to cleanse the skin and eliminate bacteria. Clients with sulfa allergies should not use sodium sulfacetamide.
No occlusive dressings over steroids
Topical corticosteroids are meant to exert a local effect; however, when these medications are covered with an occlusive dressing, systemic absorption may occur, leading to systemic side effects of the drug.
Pimecrolimus and lymphoma
Long-term use of pimecrolimus, a calcineurin inhibitor, has been associated with the development of lymphomas. For this reason, long-term use is contraindicated.
Infection is the main burn risk
The greatest risk from minor burns is infection. Because a burn removes layers of skin, an open lesion forms, breaking the skin’s integrity and allowing bacteria and other organisms to enter the client’s body.
Burn creams are sulfa compounds
As with sodium sulfacetamide, these medications are sulfa compounds that should not be administered to those with sulfa allergies.
Keep burns covered with cream
The nurse should take care to maintain a sterile environment when applying these medications to aid in preventing bacterial transfer to the client. To remain effective, burns should be completely covered with cream at all times to prevent bacterial colonization (DailyMed, Sulfamylon, 2023).
Monitor creatinine with burn creams
Monitor creatinine for decreased renal function from possible effects of systemic absorption.
Report signs of burn infection
Report drainage, odor, temperature above 100.4°F, or other unusual symptoms to the primary provider.
Terms to know
- Cutaneous warts
- Cutaneous warts are a form of localized viral infection, resulting in the familiar raised lesions known as warts.
- Contact dermatitis
- Contact dermatitis is an acute inflammation caused by aggravating factors that results in swollen, red, itchy lesions.
- Impetigo
- Impetigo is a cutaneous bacterial infection that occurs on the upper surface of the skin.
- Rosacea
- Rosacea is a skin condition that develops from an inflammatory process, causing redness, swelling, prominent small vessels, and papular lesions on the face.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client with a large second-degree burn is prescribed silver sulfadiazine cream. Which item in the client's history should the nurse report before applying it?
- Seasonal allergies to pollen
- Sulfa allergy
- History of acne
- Lactose intolerance
Answer: Sulfa allergy
Silver sulfadiazine and mafenide acetate are sulfa compounds that should not be given to clients with sulfa allergies. The other history items are not contraindications named in the section.
A client using metronidazole gel for rosacea says she plans to have wine at a party this weekend. What should the nurse explain?
- She only needs to skip the evening dose.
- Alcohol with metronidazole may cause a disulfiram-like reaction with palpitations, flushing and nausea.
- Alcohol makes the gel work faster.
- Alcohol has no effect on topical medications.
Answer: Alcohol with metronidazole may cause a disulfiram-like reaction with palpitations, flushing and nausea.
When metronidazole is absorbed systemically, mixing it with alcohol may cause a life-threatening disulfiram-like reaction with palpitations, diaphoresis, flushing, nausea and tachycardia. Skipping one dose does not remove the risk described.
The nurse is applying silver sulfadiazine to a client's burn. Which actions are appropriate? Select all that apply.
- Apply the cream with gloves.
- Keep the burn completely covered with cream.
- Cover the cream with an occlusive dressing to hold it in place.
- Maintain aseptic technique.
- Monitor creatinine for effects of systemic absorption.
Answer: Apply the cream with gloves., Keep the burn completely covered with cream., Maintain aseptic technique., Monitor creatinine for effects of systemic absorption.
The nurse applies burn creams with gloves and aseptic technique, keeps the burn fully covered with cream to prevent colonization, and monitors creatinine for systemic absorption. Occlusive dressings are contraindicated because they increase systemic absorption.
A parent wants to cover their child's hydrocortisone-treated eczema with plastic wrap overnight to make it work better. What is the nurse's best response?
- "That is a good way to increase the effect."
- "Plastic wrap will prevent all side effects."
- "Plastic wrap is only a problem with antibiotic ointments."
- "Plastic wrap can cause the steroid to be absorbed into the body and cause systemic side effects."
Answer: "Plastic wrap can cause the steroid to be absorbed into the body and cause systemic side effects."
Topical steroids are meant to act locally; under an occlusive dressing systemic absorption may occur and cause systemic side effects. Breathable gauze may be used instead.
A client with a minor burn is going home with a topical anti-infective cream. Which findings should the client report to the provider? Select all that apply.
- Drainage from the burn
- Odor from the wound
- The cream feels cool on application
- Temperature above 100.4°F
- Excessive dryness or peeling
Answer: Drainage from the burn, Odor from the wound, Temperature above 100.4°F, Excessive dryness or peeling
Clients report drainage, odor, fever above 100.4°F and side effects such as redness, excessive dryness or peeling. A cool feeling on application is not listed as a problem.
A parent asks whether their child's eczema can be treated with pimecrolimus cream every day for years. Which response is accurate?
- Long-term use is preferred because it prevents all flares.
- It is safe for continuous use in any age group.
- Long-term use is contraindicated because it has been linked to lymphomas.
- It is recommended for infants under 2 years.
Answer: Long-term use is contraindicated because it has been linked to lymphomas.
Long-term use of pimecrolimus has been associated with lymphomas and skin malignancies, so continuous long-term use is contraindicated in any age group, and it is not indicated for children under 2.
Where every quote comes from
Section 40.4 Other Dermatologic Condition Drugs and Topical Anti-infectives for Burns of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.