shift is wild

Pharmacology · chapter 4 · Introduction to Homeostasis

Osmolality

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

Skip to the questions ↓

Key points

  1. Osmolality: solutes per kilogram

    Osmolality describes the concentration of solutes in a solution. It is defined as the number of solute particles per 1 kg of solvent, also known as an osmole, or a unit of osmotic concentration.
  2. Osmolarity: solutes per liter

    Osmolarity refers to the number of solutes per 1 liter of solvent and provides valuable insight into how solutions will behave under different conditions, enabling the manipulation of their properties to achieve optimal changes within the body.
  3. Which solutes are measured

    Osmolality is a measure of the concentration of solutes, such as sodium, glucose, and urea, in a solution; specifically, it refers to the number of particles per kilogram of solvent.
  4. Causes of hyperosmolality

    This can be caused by various factors, such as dehydration, diabetes, and certain drugs.
  5. Dangers of hyperosmolality

    Hyperosmolality may have serious consequences, such as impairment of the cardiovascular and circulatory system, as well as neurologic signs and symptoms such as irritability, seizures, and, in severe cases, coma.
  6. Hypoosmolality: solutes below normal

    Hypoosmolality refers to a state in which the concentration of solutes in a solution is lower than normal.
  7. Causes of hypoosmolality

    This can be caused by a variety of factors, including excessive water intake, certain drugs, disorders affecting the kidneys, and hormonal dysregulation of water balance.
  8. Hypoosmolality can lead to coma

    Hypoosmolality can have serious consequences, including neurologic signs and symptoms and even coma if not corrected.
  9. Osmolality and tonicity differ

    Tonicity Although osmolality and tonicity are related, they are not the same.
  10. Hypertonic solutions shrink cells

    This state can cause water to move out of the cell, potentially leading to cell shrinkage and changes in cell function.
  11. Causes of hypertonicity

    Hypertonicity can be caused by a variety of factors, including dehydration and increased solute concentration in a solution, such as with high glucose levels in the blood.
  12. Hypotonic solutions swell cells

    It is a state in which the tonicity of a solution is less than that of the cytoplasm of a cell. Water can then move into the cell, potentially leading to swelling and other changes in cell function.
  13. Causes of hypotonicity

    Hypotonicity can be caused by a variety of factors, including excessive water intake and certain medical conditions.
  14. Isotonic: no net water movement

    This means the concentration of solutes in the solution is balanced with the concentration of solutes inside the cell, resulting in no net movement of water into or out of the cell.

Terms to know

Tonicity
Tonicity refers to the ability of a solution to cause a cell to gain or lose water and is relative to the cytoplasm of a cell (Khan Farhana, 2023; Maldonado Mohiuddin, 2022).
Hypertonicity
A change in tonicity can have significant effects on cell function and overall fluid and electrolyte balance within the body, such as: Hypertonicity occurs when the tonicity of a solution is greater than that of the cytoplasm of a cell.
Isotonicity
Isotonicity exists when the tonicity of a solution is equal to that of the cytoplasm of a cell.
Iso-osmolality
Iso-osmolality occurs when the concentration of solute particles per unit of volume in a solution is equal to a standard reference value.
Hypoosmolality
Hypoosmolality refers to a state in which the concentration of solutes in a solution is lower than normal.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client with poorly controlled diabetes has a very high blood glucose level. Which change should the nurse expect in the client's cells?

    1. Water moves into the cells and they swell.
    2. The cells gain sodium and burst.
    3. There is no net movement of water.
    4. Water moves out of the cells and they shrink.

    Answer: Water moves out of the cells and they shrink.

    High blood glucose raises solute concentration and makes the blood hypertonic compared with the cytoplasm, so water moves out of the cells and they shrink. Swelling happens with hypotonicity, and no net movement happens only with isotonicity.

  2. A nurse is assessing a client with a high serum osmolality. Which findings should the nurse watch for? Select all that apply.

    1. Decreasing level of consciousness
    2. Hair loss
    3. Seizures
    4. Increased appetite
    5. Irritability

    Answer: Decreasing level of consciousness, Seizures, Irritability

    Hyperosmolality can cause neurologic signs such as irritability, seizures and, in severe cases, coma, as well as cardiovascular impairment. Appetite and hair changes are not described.

  3. A client drank a very large amount of water in a short time and now has a low serum osmolality. What should the nurse understand about this state?

    1. It can cause neurologic signs and even coma if not corrected.
    2. It causes the cells to shrink.
    3. It only affects the urine, not the blood.
    4. It is harmless because the kidneys always correct it.

    Answer: It can cause neurologic signs and even coma if not corrected.

    Excessive water intake is a cause of hypoosmolality, which can cause neurologic signs and even coma if not corrected. It lowers solute concentration, so cells swell rather than shrink.

  4. Which factors can cause hypoosmolality? Select all that apply.

    1. Excessive water intake
    2. Certain drugs
    3. Hormonal dysregulation of water balance
    4. Dehydration
    5. Disorders affecting the kidneys

    Answer: Excessive water intake, Certain drugs, Hormonal dysregulation of water balance, Disorders affecting the kidneys

    Hypoosmolality can be caused by excessive water intake, certain drugs, kidney disorders and hormonal dysregulation of water balance. Dehydration raises solute concentration and is a cause of hyperosmolality.

  5. A student asks the nurse what an isotonic solution does to a cell. Which answer is correct?

    1. It causes no net movement of water into or out of the cell.
    2. It pulls water out of the cell.
    3. It pushes water into the cell.
    4. It raises the solute concentration inside the cell.

    Answer: It causes no net movement of water into or out of the cell.

    An isotonic solution has the same tonicity as the cytoplasm, so solutes are balanced and there is no net movement of water. Water leaves the cell with a hypertonic solution and enters it with a hypotonic one.

  6. Which statement about osmolality and tonicity is accurate?

    1. Tonicity describes the ability of a solution to make a cell gain or lose water.
    2. Tonicity is measured only in urine.
    3. Osmolality is measured per liter of solvent.
    4. They are two names for the same measurement.

    Answer: Tonicity describes the ability of a solution to make a cell gain or lose water.

    Osmolality and tonicity are related but not the same: tonicity is the ability of a solution to make a cell gain or lose water, relative to the cytoplasm. Osmolality is per kilogram of solvent; per liter is osmolarity.

Where every quote comes from

Section 4.2 Osmolality of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.