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Pharmacology · chapter 14 · Pain Response Drugs

Nonopioid Analgesics

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. What a nonopioid analgesic is

    A nonopioid analgesic refers to any pharmacologic agent that treats the symptoms of pain and does not involve activation of opioid receptors.
  2. Why COX blockers also lower fever

    It is also partly responsible for the pyrexia that occurs with infection, which is why many nonopioid analgesics that block the activity of COX also work as antipyretics to reduce fever.
  3. COX-1 inhibition and peptic ulcers

    If COX-1 is inhibited through the actions of medications such as glucocorticoids or nonsteroidal anti-inflammatory drugs (NSAIDs), this protective barrier can erode, which is a major cause of peptic ulcers.
  4. Acetaminophen has no anti-inflammatory action

    Some experts theorize that it inhibits COX in the central nervous system (CNS), providing analgesic and antipyretic actions, but notably it does not inhibit COX peripherally, meaning it has no anti-inflammatory action as compared with other nonopioid analgesics.
  5. Look for every source of acetaminophen

    Because acetaminophen is present in so many products, and because its overuse can lead to serious adverse events, nurses must be alert for all sources of acetaminophen that clients may be taking.
  6. Aspirin affects platelets for their lifetime

    Aspirin’s irreversible inhibition of COX means that platelets are affected for their entire lifetime, which is approximately 7–10 days.
  7. Aspirin with blood thinners

    Nurses should instruct clients taking blood thinners (e.g., warfarin, apixaban) to be cautious about using aspirin to treat pain because of increased risk for bleeding and bruising.
  8. Signs of a stomach ulcer on NSAIDs

    Clients reporting severe abdominal pain, dark tarry stools, or vomiting or coughing up of blood should stop using any NSAIDs immediately and be assessed by a health care provider for possible stomach ulcers.
  9. Acetaminophen daily limit and liver toxicity

    This limit is 4000 mg per 24 hours; taking acetaminophen in doses beyond that increases the chances of developing potentially fatal hepatotoxicity.
  10. Signs of acetaminophen hepatotoxicity

    Hepatotoxicity from acetaminophen can present as nausea, fatigue, and jaundice (yellowish skin and sclera) and may require antidotal therapy with the drug n-acetylcysteine to help prevent further liver injury.
  11. NSAIDs, bleeding and kidney injury

    NSAIDs such as aspirin, ibuprofen, and naproxen sodium are known to increase the risk for bleeding and bruising and can cause kidney injury in older adults and in clients with a history of chronic kidney disease.
  12. Tramadol and respiratory depression

    Due to its opioid receptor activity, tramadol can cause CNS and respiratory depression in overdose or when mixed with other CNS depressants such as alcohol.
  13. Tramadol and seizures

    Tramadol can lower the seizure threshold and should be used with caution in clients with a history of seizure disorder.
  14. Aspirin, children and Reye’s syndrome

    Aspirin should be avoided in children younger than 16 years old with a recent history of viral illness because the medication may cause a potentially fatal condition called Reye’s syndrome.

Terms to know

Nonopioid analgesic
A nonopioid analgesic refers to any pharmacologic agent that treats the symptoms of pain and does not involve activation of opioid receptors.
NSAIDs
Aspirin, ibuprofen, and naproxen sodium are classified as nonsteroidal anti-inflammatory drugs (NSAIDs).
Tramadol
Tramadol is a partial opioid receptor agonist and inhibitor of reuptake of the neurotransmitters norepinephrine and serotonin.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

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Every question here, with the answer

  1. A client takes acetaminophen for back pain and also uses an over-the-counter cold medicine. What is the priority nursing action?

    1. Suggest switching the cold medicine to a larger dose.
    2. Check whether the cold medicine also contains acetaminophen and total all sources.
    3. Tell the client to take the cold medicine at bedtime only.
    4. Advise taking the acetaminophen with milk.

    Answer: Check whether the cold medicine also contains acetaminophen and total all sources.

    Many cough and cold products contain acetaminophen, so the client must count every source to stay under the daily limit and avoid liver injury. Timing, larger doses of the cold product or taking it with milk do nothing about the hidden acetaminophen.

  2. A client who takes warfarin asks whether aspirin is a good choice for a headache. What should the nurse teach?

    1. Aspirin is preferred because it works only in the brain.
    2. Be cautious with aspirin because it increases the risk for bleeding and bruising.
    3. Aspirin will cancel out the effect of warfarin.
    4. Aspirin is safe because it has no effect on platelets.

    Answer: Be cautious with aspirin because it increases the risk for bleeding and bruising.

    Aspirin irreversibly inhibits COX in platelets, so a client on a blood thinner has an increased risk for bleeding and bruising. Aspirin does affect platelets, does not cancel warfarin, and acts peripherally as well as centrally.

  3. A client has been taking ibuprofen daily for arthritis. Which findings should the nurse tell the client to report to the health care provider? Select all that apply.

    1. Black tarry stools
    2. Throat swelling or chest tightness
    3. Blood-streaked sputum
    4. Mild relief of joint pain
    5. Coffee-ground emesis

    Answer: Black tarry stools, Throat swelling or chest tightness, Blood-streaked sputum, Coffee-ground emesis

    Black tarry stools, coffee-ground emesis and blood-streaked sputum are signs of bleeding, and throat swelling or chest tightness are signs of an allergic reaction; all must be reported. Relief of joint pain is the expected therapeutic effect.

  4. A 12-year-old is recovering from a viral illness and has a fever. The parent asks if aspirin can be given. What is the nurse's best response?

    1. Yes, but give it with food.
    2. Yes, aspirin is the preferred fever reducer for children.
    3. No, aspirin does not reduce fever.
    4. No, aspirin in this situation may cause a potentially fatal condition called Reye’s syndrome.

    Answer: No, aspirin in this situation may cause a potentially fatal condition called Reye’s syndrome.

    Aspirin should be avoided in children younger than 16 with a recent viral illness because of the risk of Reye’s syndrome. Giving it with food does not remove this risk, and aspirin does have antipyretic action.

  5. The nurse reviews a client's history before starting tramadol. Which findings call for caution or avoidance? Select all that apply.

    1. Neuropathic pain
    2. Allergy to penicillin
    3. Regular alcohol use
    4. History of seizure disorder
    5. History of substance use disorder

    Answer: Regular alcohol use, History of seizure disorder, History of substance use disorder

    Tramadol lowers the seizure threshold, carries a risk of misuse and addiction, and can cause CNS and respiratory depression when mixed with alcohol. Neuropathic pain is a reason to consider tramadol, and a penicillin allergy is not related to it.

  6. A client with a history of heavy acetaminophen use reports nausea and fatigue, and the nurse notes yellowing of the sclera. What does the nurse suspect?

    1. Peptic ulcer from COX-1 inhibition
    2. Reye’s syndrome
    3. Hepatotoxicity from acetaminophen
    4. Aspirin-induced asthma

    Answer: Hepatotoxicity from acetaminophen

    Nausea, fatigue and jaundice are how acetaminophen hepatotoxicity presents, and it may need n-acetylcysteine. Peptic ulcers are linked to NSAIDs, Reye’s syndrome to aspirin in children, and asthma exacerbation to NSAIDs.

Where every quote comes from

Section 14.2 Nonopioid Analgesics of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.