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Pharmacology · chapter 13 · Psychopharmacologic Drugs

Mood Stabilizers

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. Antidepressant alone can trigger mania

    However, if a client has an undiagnosed bipolar disorder, putting them solely on an antidepressant can cause the client to experience one or more manic phases.
  2. Lithium as the gold standard

    It has historically been the “gold standard” mood stabilizer, effectively controlling manic episodes as well as decreasing the frequency and intensity of manic cycles (Volkmann et al., 2020).
  3. Narrow margin of safety

    Lithium has a narrow margin of safety; even small increases in the dose could be toxic (Hedya et al., 2023).
  4. Target serum lithium level

    The goal is to initially maintain the serum lithium level between 0.6 and 1.2 mEq/L (Coryell, 2022). Target maintenance drug levels are closer to 0.6 mEq/L.
  5. Lithium and sodium balance

    Because lithium is tied to sodium resorption, any drug that affects sodium balance may alter lithium concentrations, leading to either treatment failure or toxicity. Examples include diuretics, NSAIDs, and angiotensin-converting enzyme (ACE) inhibitors.
  6. Other lithium drug interactions

    Lithium interacts with other medications including carbamazepine (CNS toxicity), neuromuscular blocking agents (prolonged effects), and other serotonergic drugs (serotonin syndrome).
  7. Addison's disease is a contraindication

    Addison’s disease is a contraindication because the person is losing more sodium through the kidneys due to the lack of aldosterone.
  8. Lithium and the thyroid

    Lithium inhibits the synthesis and release of thyroid hormones, resulting in hypothyroidism.
  9. Monitor renal function

    Monitor client’s renal function while on lithium.
  10. Report bruising, bleeding, fever or jaundice

    Notify the health care provider with unusual and easy bruising, blood in the urine or stool, fever, sore throat, right upper quadrant pain, and jaundice.
  11. Carbamazepine and hormonal contraceptives

    Consider an additional or alternate form of contraception because carbamazepine decreases the effectiveness of certain hormonal contraceptives.
  12. Fluids to prevent lithium toxicity

    Drink 8–12 glasses of water daily to prevent dehydration, which could cause lithium toxicity. Also, maintain a consistent sodium intake.
  13. Therapy is long term

    Continue taking the medication as prescribed despite their symptoms subsiding because this type of therapy is long term.
  14. Signs of overdose

    Notify the health care provider and stop taking the drug immediately if manifestations of overdose occur (vomiting, diarrhea, ataxia, tremor, drowsiness, and muscle weakness).

Terms to know

Bipolar disorder
Bipolar disorder is a complex brain-based illness with a primary characteristic of mood disturbance.
Mania
Mania involves a period of abnormally and persistently elevated or irritable mood and increased goal-directed activity or energy (American Psychiatric Association, 2022).
Bipolar Type 1
Bipolar Type 1 is characterized by the occurrence of one or more manic episodes interspersed with major depression.
Bipolar Type 2
Bipolar Type 2 is characterized by occurrence of one or more major depressive episodes accompanied by at least one manic or hypomanic episode (persistent irritability without euphoria) (NIMH, 2023a).

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client on long-term lithium has had vomiting, diarrhea, a new tremor and muscle weakness since yesterday. What should the nurse tell the client to do?

    1. Take an extra dose to make up for what was lost by vomiting.
    2. Reduce salt intake until the diarrhea stops.
    3. Stop taking the drug and notify the health care provider immediately.
    4. Continue the drug and increase exercise to feel stronger.

    Answer: Stop taking the drug and notify the health care provider immediately.

    Vomiting, diarrhea, ataxia, tremor, drowsiness and muscle weakness are manifestations of lithium overdose; the client stops the drug and notifies the provider immediately. An extra dose adds to toxicity, lowering salt raises lithium levels, and exercise worsens dehydration.

  2. A client stabilized on lithium is prescribed a diuretic for hypertension. Why should the nurse be concerned?

    1. Diuretics make lithium work faster with no other effect.
    2. Diuretics prevent lithium from reaching the brain.
    3. Drugs that affect sodium balance can alter lithium levels and lead to toxicity or treatment failure.
    4. There is no interaction between lithium and diuretics.

    Answer: Drugs that affect sodium balance can alter lithium levels and lead to toxicity or treatment failure.

    Lithium is tied to sodium resorption, so any drug that affects sodium balance, such as diuretics, NSAIDs and ACE inhibitors, may alter lithium concentrations and cause toxicity or treatment failure. The other options ignore or misstate this interaction.

  3. The nurse is teaching a client who is starting lithium. Which instructions should be included? Select all that apply.

    1. Keep your sodium intake consistent.
    2. Cut out salt completely to protect your heart.
    3. Do not take the morning dose until the blood sample for the lithium level is drawn.
    4. Increase your exercise routine during hot weather.
    5. Drink 8 to 12 glasses of water daily.

    Answer: Keep your sodium intake consistent., Do not take the morning dose until the blood sample for the lithium level is drawn., Drink 8 to 12 glasses of water daily.

    Adequate water prevents dehydration that could cause lithium toxicity, a consistent sodium intake keeps levels stable, and the morning dose is held until the blood sample is obtained. Extra exercise in hot weather raises the risk of dehydration and toxicity, and decreasing salt can cause lithium toxicity.

  4. A client with Addison's disease is being evaluated for bipolar disorder. Why is lithium contraindicated for this client?

    1. Lithium raises aldosterone to dangerous levels.
    2. Lithium is not absorbed in clients with Addison's disease.
    3. Lithium causes hyperthyroidism in these clients.
    4. Loss of sodium through the kidneys causes lithium to be reabsorbed, quickly leading to toxicity.

    Answer: Loss of sodium through the kidneys causes lithium to be reabsorbed, quickly leading to toxicity.

    In Addison's disease the person loses more sodium through the kidneys because of the lack of aldosterone, so the kidneys reabsorb lithium back into the bloodstream, which can quickly cause toxicity. The other options are not supported; lithium causes hypothyroidism, not hyperthyroidism.

  5. A nurse is caring for a client taking a mood stabilizer. Which actions are appropriate? Select all that apply.

    1. Stop lithium abruptly if the client's mood improves.
    2. Monitor renal function while the client is on lithium.
    3. Encourage the client to reduce dietary salt.
    4. Assess for suicidal ideation.
    5. Obtain a baseline electrocardiogram.

    Answer: Monitor renal function while the client is on lithium., Assess for suicidal ideation., Obtain a baseline electrocardiogram.

    Nursing care includes a baseline electrocardiogram, assessment for suicidal ideation with precautions for at-risk clients, and monitoring renal function on lithium. Lithium should not be stopped abruptly, and decreasing salt can cause lithium toxicity.

  6. A client taking carbamazepine for bipolar disorder uses an oral hormonal contraceptive. What should the nurse teach?

    1. Carbamazepine makes hormonal contraceptives more effective.
    2. Consider an additional or alternate form of contraception.
    3. No change is needed because there is no interaction.
    4. Stop carbamazepine while taking the contraceptive.

    Answer: Consider an additional or alternate form of contraception.

    Carbamazepine decreases the effectiveness of certain hormonal contraceptives, so the client should consider an additional or alternate form of contraception. It does not increase their effect, and stopping the mood stabilizer is not the teaching.

Where every quote comes from

Section 13.3 Mood Stabilizers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.