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Pharmacology · chapter 7 · Anti-infective Drugs

Introduction to Sexually Transmitted Infections and Drugs to Treat Them

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. A nonjudgmental approach

    Nurses should always adopt a curious, nonjudgmental approach with clients to encourage open and honest communication so that clients get the care they need and deserve.
  2. Untreated chlamydia

    Untreated cases of chlamydia can progress to PID in female clients, which may result in chronic pain and infertility.
  3. Primary and secondary syphilis

    Primary syphilis is associated with a painless chancre on tissue that was exposed to the organism (usually the genital tissue). Secondary syphilis occurs as the organism spreads through the lymph system, producing skin lesions throughout the body.
  4. Viral STIs are usually not curable

    Unlike bacterial STIs, most of the viral STIs do not have definitive curative therapy, meaning these infections may become lifelong conditions to manage.
  5. Latex or polyisoprene, not lambskin

    Clients should be instructed to use either latex or polyisoprene condoms because lambskin condoms are too porous to prevent the transmission of many organisms that cause STIs.
  6. Vaccinate before sexual activity

    Vaccines should be given before the onset of sexual activity because they will have little efficacy if the client has already been infected.
  7. Test the sexual partners too

    When diagnosed with an STI, the client should be encouraged to have their sexual partners tested as well because many infections may be asymptomatic.
  8. Metronidazole for BV and trichomoniasis

    For this reason, metronidazole is recommended for treatment of BV and trichomoniasis. The client’s sexual partners should also be treated with metronidazole to prevent reinfection.
  9. Penicillin for syphilis

    Penicillin: Penicillin is considered the treatment of choice for syphilis. It can be given as a single-dose, long-acting intramuscular injection to assist with client adherence.
  10. Ceftriaxone for gonorrhea

    It can be given as a single intramuscular injection for most cases of uncomplicated gonorrhea. The main adverse effect expected with this treatment is pain at the injection site, which can be offset by mixing ceftriaxone with a local anesthetic such as lidocaine.
  11. Doxycycline for chlamydia: every dose

    The downside of doxycycline is that it must be given twice daily over 7 days, so nurses should impress upon the client the need to take all doses to prevent treatment failure and to control resistance.
  12. Doxycycline: calcium, iron and sun

    It is important to educate clients using doxycycline to avoid taking the medication with calcium- or iron-containing products to ensure absorption. Clients should also be instructed to avoid prolonged sun exposure and to use appropriate sun protection (e.g., physical coverings, sunscreen) to prevent sunburn.
  13. Herpes spreads without lesions

    Nurses should inform clients taking antivirals for STIs that even if they do not have active lesions, viral shedding can still occur and thereby spread the infection to partners.
  14. Start HSV antivirals within 24 hours

    If clients are taking antivirals for episodic management of HSV-related lesions, they should begin therapy within 24 hours of symptom onset to ensure drug efficacy.

Terms to know

Bacterial vaginosis
Bacterial Vaginosis Bacterial vaginosis (BV) is a common cause of vaginal discharge and occurs when the normal bacterial flora of the vagina shift from the normally dominant lactobacilli to other pathogenic species.
Congenital syphilis
Congenital syphilis occurs when an infant acquires the infection in utero from the birthing parent, and it is a cause of stillbirths and infant deaths.
Chronic suppressive therapy
Chronic suppressive therapy, in which clients take the medication every day regardless of symptom status, can help prevent spread to sexual partners, but nurses should instruct clients to use additional protective measures such as condoms if the partner does not have HSV.
trichomoniasis
Other Pathogenic Infections A variety of other microorganisms are responsible for STIs, including trichomoniasis, a genitourinary infection that is caused by the protozoan parasite Trichomonas vaginalis.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

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Every question here, with the answer

  1. A client is prescribed doxycycline for chlamydia. Which instruction should the nurse include?

    1. You can stop once the discharge clears up.
    2. Take it with a glass of milk to protect your stomach.
    3. Take it together with your daily iron tablet.
    4. Avoid prolonged sun exposure and use sunscreen or protective clothing.

    Answer: Avoid prolonged sun exposure and use sunscreen or protective clothing.

    Doxycycline can cause sunburn, so clients should avoid prolonged sun and use sun protection. Calcium- and iron-containing products such as milk and iron tablets block its absorption, and all doses over 7 days must be taken to prevent treatment failure and resistance.

  2. A client with genital herpes on daily suppressive valacyclovir says, 'Since I have no sores, I can't pass it to my partner.' What is the nurse's best response?

    1. The virus can still be shed without active lesions, so use condoms.
    2. Your partner should take your medication too.
    3. You only need condoms during the first week of treatment.
    4. That is correct, the medication cures the infection.

    Answer: The virus can still be shed without active lesions, so use condoms.

    Antivirals do not cure HSV, and viral shedding can occur even without active lesions, so barrier methods such as condoms are still needed. The medication is not curative, protection is not limited to the first week, and sharing the client's medication is not the teaching.

  3. A client asks which condoms best protect against STIs. Which answer is correct?

    1. Latex or polyisoprene condoms.
    2. Condoms do not reduce STI risk.
    3. Lambskin condoms, because they are natural.
    4. Any type works the same.

    Answer: Latex or polyisoprene condoms.

    Clients should use latex or polyisoprene condoms because lambskin condoms are too porous to stop many organisms that cause STIs. Correct and consistent condom use does reduce the risk of transmission.

  4. A nurse is preparing an intramuscular injection of ceftriaxone for a client with uncomplicated gonorrhea. Which action does the nurse take, as ordered, to reduce the main expected adverse effect?

    1. Give it as a continuous IV infusion.
    2. Split it into several daily injections.
    3. Mix the ceftriaxone with lidocaine.
    4. Give it with food.

    Answer: Mix the ceftriaxone with lidocaine.

    The main adverse effect of ceftriaxone for gonorrhea is pain at the injection site, which can be offset by mixing it with a local anesthetic such as lidocaine. It is given as a single intramuscular injection, so food, split doses or an infusion do not address the injection pain.

  5. A client is being treated with metronidazole for trichomoniasis. Which teaching points should the nurse include? Select all that apply.

    1. Refrain from sexual activity while taking the medication.
    2. Stop the drug once symptoms improve.
    3. Your sexual partners should also be tested and treated.
    4. Avoid alcohol during treatment.
    5. A lambskin condom will protect your partner.

    Answer: Refrain from sexual activity while taking the medication., Your sexual partners should also be tested and treated., Avoid alcohol during treatment.

    Alcohol should be avoided with metronidazole, sexual activity should stop during treatment, and partners should be tested and treated to prevent reinfection. The whole course must be taken, and lambskin condoms are too porous to prevent many STIs.

  6. A client is prescribed ciprofloxacin as an alternative treatment. Which products should the client avoid taking at the same time? Select all that apply.

    1. Multivitamins
    2. Water
    3. Milk
    4. Iron supplements
    5. Yogurt

    Answer: Multivitamins, Milk, Iron supplements, Yogurt

    Iron and calcium bind to ciprofloxacin and make it ineffective, so multivitamins, dairy products and iron-containing products should be avoided with the dose. Water does not interfere, and adequate hydration is encouraged.

Where every quote comes from

Section 7.4 Introduction to Sexually Transmitted Infections and Drugs to Treat Them of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.