shift is wild

Pharmacology · chapter 10 · Drugs to Treat Myasthenia Gravis and Alzheimer’s Disease

Introduction to Alzheimer’s Disease

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

Skip to the questions ↓

Key points

  1. Most common cause of dementia

    Alzheimer’s disease (AD) is the most common neurodegenerative condition of the brain and is characterized by significant changes in brain tissue. This disease is the most frequent cause of dementia in older adults.
  2. What the disease takes away

    Alzheimer’s is irreversible and eventually has a major negative impact on cognition due to loss of short-term memory, reasoning, insight, and judgment and the inability to learn new information.
  3. Factors that may reduce risk

    These include higher levels of formal education, routinely engaging in mentally challenging activities—such as reading—adequate uninterrupted deep sleep, engaging in routine aerobic exercise, eating a healthy balanced diet, and maintaining social interactions.
  4. Two major goals of care

    Two major goals of care are maintaining socialization and providing support for caregivers. One way to provide relief for caregivers while increasing socialization for clients is adult daycare and respite centers.
  5. Hippocampus and short-term memory

    This destruction of neurons first occurs in the hippocampus, the area of the brain that plays an essential role in memory. The degeneration of these neurons will cause short-term memory loss.
  6. Beta-amyloid appears early

    Accumulation of beta-amyloid begins very early in the disease before any appearance of clinical manifestations. It is believed this protein plays a central role in AD.
  7. Sticky tau protein

    In AD, tau protein becomes “sticky” and tangles together with other tau threads. The microtubule is unable to transport nutrients, so the neuron can no longer function and eventually dies.
  8. Why losing acetylcholine matters

    Deficiency of ACh: The loss of ACh is crucial for two reasons: (1) it is an important transmitter in the hippocampus and cerebral cortex, where the degeneration is occurring; and (2) this transmitter is critical in forming memories.
  9. APOE-e4 raises risk

    Genetic research has shown that those with one or two copies of the gene that codes for apolipoprotein E4 (APOE-e4) are at a higher risk for developing AD.
  10. How the diagnosis is made

    Although it is impossible to definitively diagnose AD without a postmortem autopsy, the diagnosis is made based on symptoms and exclusion of alternative pathology.
  11. Early, mild manifestations

    Early in the disease, the following mild manifestations may be witnessed: confusion, memory loss, disorientation, getting lost in familiar surroundings, problems with routine tasks, and changes in personality and judgment.
  12. Moderate manifestations

    Moderate manifestations include difficulty with ADLs (feeding and bathing), impaired organization and planning, impaired mathematical ability, anxiety/agitation, sleep disturbances, wandering, and difficulty in recognizing family and friends.
  13. What drugs can and cannot do

    Currently, there is no known cure for AD. Drugs given for AD may at best slow the loss of memory and cognition in hopes of affording the person extra time to be able to continue functioning independently.
  14. AChE inhibitors were approved first

    The AChE inhibitors (also known as cholinesterase inhibitors) were the first class of drugs approved by the FDA to treat AD. There are currently three drugs within this class.

Terms to know

beta-amyloid
Their central core is composed of beta-amyloid, a protein fragment of amyloid precursor protein (APP).
Oxidative stress
Oxidative stress is the term used to describe damage to cellular components caused by ROS.
NMDA
The other drug class, which currently contains one drug, is the N-methyl-D-aspartate (NMDA) receptor antagonist.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. The daughter of a client newly diagnosed with Alzheimer's disease asks whether the prescribed medication will cure her mother. Which response by the nurse is accurate?

    1. Yes, the medication reverses the brain changes if started early.
    2. The medication only works for people younger than 60.
    3. The medication is only used after the disease becomes severe.
    4. The medication may at best slow the loss of memory and thinking, but there is no known cure.

    Answer: The medication may at best slow the loss of memory and thinking, but there is no known cure.

    There is no known cure for AD, and drugs may at best slow the loss of memory and cognition. AD is irreversible, and the section gives no age or severity restriction of this kind.

  2. A nurse is teaching a community group about factors that may reduce the risk of Alzheimer's disease. Which factors should the nurse include? Select all that apply.

    1. Mentally challenging activities such as reading
    2. Maintaining social interactions
    3. Adequate uninterrupted deep sleep
    4. Avoiding all dietary fat
    5. Routine aerobic exercise

    Answer: Mentally challenging activities such as reading, Maintaining social interactions, Adequate uninterrupted deep sleep, Routine aerobic exercise

    Aerobic exercise, deep sleep, social interaction and mentally challenging activities are listed as factors that may reduce risk. The section recommends a healthy balanced diet, not avoiding all fat.

  3. The spouse of a client with Alzheimer's disease reports feeling exhausted from providing care at home. Which intervention best meets the goals of care for both of them?

    1. Recommend limiting the client's contact with visitors.
    2. Request a higher medication dose to reduce care needs.
    3. Suggest an adult daycare or respite center.
    4. Advise the spouse to keep the client at home alone during the day.

    Answer: Suggest an adult daycare or respite center.

    Maintaining socialization and supporting caregivers are the two major goals, and adult daycare and respite centers do both. Isolating the client works against socialization, and medication does not relieve caregiver burden in this way.

  4. A client with early Alzheimer's disease repeats the same question minutes after it was answered. The nurse knows this short-term memory loss is linked to degeneration in which area?

    1. Brain stem
    2. Cerebellum
    3. Spinal cord
    4. Hippocampus

    Answer: Hippocampus

    Neuron destruction first occurs in the hippocampus, which plays an essential role in memory, causing short-term memory loss. The cerebellum, brain stem and spinal cord are not described as the first sites of degeneration.

  5. A nurse is assessing a client with moderate Alzheimer's disease. Which findings are consistent with this stage? Select all that apply.

    1. Sleep disturbances
    2. Difficulty with feeding and bathing
    3. Difficulty recognizing family and friends
    4. Wandering
    5. Complete loss of speech

    Answer: Sleep disturbances, Difficulty with feeding and bathing, Difficulty recognizing family and friends, Wandering

    Wandering, sleep disturbances, difficulty with ADLs and trouble recognizing family and friends are moderate manifestations. Loss of speech is listed as a late manifestation.

  6. A family member asks how the health care provider diagnosed Alzheimer's disease without a definitive test. Which explanation by the nurse is correct?

    1. The diagnosis is made from a genetic test for APOE-e4.
    2. The diagnosis is based on symptoms and ruling out other causes.
    3. A blood test confirms the disease.
    4. A single brain scan confirms the disease.

    Answer: The diagnosis is based on symptoms and ruling out other causes.

    AD cannot be definitively diagnosed without autopsy, so the diagnosis is based on symptoms and exclusion of other pathology. APOE-e4 only raises risk, and no blood test or scan is described as confirming AD.

Where every quote comes from

Section 10.3 Introduction to Alzheimer’s Disease of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.