Pharmacology · chapter 12 · Anticonvulsant Drugs and Drugs to Treat Epilepsy, Migraine Headaches, and Intracranial Emergencies
Intracranial Emergencies and Intracranial Emergency Drugs
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Early recognition matters
Successful treatment of intracranial emergencies requires early recognition and prompt medical intervention. Delayed treatment can lead to irreversible brain damage or death.
Symptoms of increased intracranial pressure
However, increased intracranial pressure refers to a rise in the pressure within the skull that can cause various symptoms, such as headache, nausea, vomiting, visual changes, and altered mental status.
Normal intracranial pressure
Intracranial pressure is typically measured at the level of the foramen of Monro and is normally between 7 mm Hg and 15 mm Hg in vertically positioned adults.
When to start lowering pressure
Therapy to lower intracranial pressure should be initiated when increased intracranial pressure is greater than 20 mm Hg to 25 mm Hg (Munakomi Das, 2023).
The gold standard measurement
Direct measurement of intracranial pressure can be obtained by inserting a catheter into the skull and connecting it to a pressure transducer. This is the “gold standard” for diagnosing and monitoring increased intracranial pressure.
Signs of brain herniation
Symptoms of brain herniation can include changes in breathing pattern, dilation of one or both pupils, loss of consciousness, coma, and death.
Head of bed and neck position
Along with administering drugs to decrease elevated intracranial pressure, the nurse must keep the head of the client’s bed at a 30-degree angle, or as directed by the health care provider, and keep the client’s neck in a neutral position to help stabilize and lower intracranial pressure (Faraj et al., 2022).
How CAIs lower pressure
This decrease in bicarbonate ion secretion leads to a reduction in cerebrospinal fluid and intracranial pressure, making CAIs an important therapeutic option for managing intracranial hypertension (Aslam Gupta, 2022).
Serious CAI adverse effects
Serious adverse effects include hypokalemia, metabolic acidosis, aplastic anemia, fulminant hepatic necrosis, and nephrolithiasis.
CAI contraindications
CAIs are contraindicated in clients with hepatic disease, in those with certain electrolytes imbalances—such as hypokalemia and hyponatremia—and in those with hypersensitivity to the drug or its components (Aslam Gupta, 2022).
Acetazolamide with high-dose aspirin
Caution is advised for client’s receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, metabolic acidosis, and death have been reported.
Osmotic diuretic adverse effects
Adverse effects include dehydration, heart failure due to the shift of free water, hyponatremia, hypokalemia, and hypocalcemia.
Osmotic diuretic contraindications
Osmotic diuretics are contraindicated in clients with anuria due to renal disease, pulmonary edema, severe dehydration, progressive heart failure, and in those with hypersensitivity to the drug or any of its compounds (Tenny et al., 2022).
Inspect mannitol before giving
Mannitol administration preparation should include inspecting the injection for particulate matter, discoloration, or crystallization before and periodically during administration. Discard the mannitol solution if particulates, crystallization, or discoloration are present.
Terms to know
- Intracranial hypertension
- Intracranial hypertension refers specifically to an elevated pressure within the skull that may or may not cause symptoms.
- brain herniation
- In severe cases, increased intracranial pressure can lead to brain herniation, a condition in which a portion of the brain is displaced due to increased intracranial pressure, a life-threatening condition.
- Osmotic diuretics
- Osmotic diuretics are a class of drugs that primarily function by inhibiting the reabsorption of water in the proximal convoluted tubule, the descending loop of Henle, and the collecting duct, all of which are regions of the kidney that are highly permeable to water.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
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Every question here, with the answer
A client with increased intracranial pressure is receiving mannitol. Which positioning should the nurse maintain unless directed otherwise?
- Head of bed at 30 degrees with the neck in a neutral position.
- Trendelenburg position.
- Flat in bed with the head turned to the side.
- Head of bed at 30 degrees with the neck flexed forward.
Answer: Head of bed at 30 degrees with the neck in a neutral position.
Along with drugs, the nurse keeps the head of the bed at 30 degrees and the neck neutral to help stabilize and lower intracranial pressure. Lying flat, head-down positioning or a flexed or turned neck do not follow this guidance.
While preparing a mannitol infusion, the nurse sees crystals in the solution. What should the nurse do?
- Discard the solution.
- Shake the bag until the crystals disappear, then give it.
- Give it through a larger IV catheter.
- Give it slowly over a longer period.
Answer: Discard the solution.
Mannitol is inspected for particulate matter, discoloration or crystallization before and during administration, and the solution is discarded if any are present. The other options give a solution that should not be given.
A nurse is caring for a client at risk for cerebral edema. Which findings should the nurse report to the health care provider? Select all that apply.
- Pupils that do not react to light
- Increased urine output after mannitol
- Bradycardia
- Improved coordination
- New confusion
Answer: Pupils that do not react to light, Bradycardia, New confusion
Symptoms of cerebral edema and intracranial hypertension to report include headache, confusion, dizziness, convulsions, unconsciousness, bradycardia, and failure of the pupils to react to light. Increased urine output and improved coordination are listed as signs that pressure and edema are decreasing.
A client with idiopathic intracranial hypertension is prescribed acetazolamide. The client also takes high-dose aspirin. Which complication should the nurse watch for?
- Hypertensive crisis
- Metabolic acidosis
- Hyperkalemia
- Hypercalcemia
Answer: Metabolic acidosis
Concomitant high-dose aspirin and acetazolamide has been reported to cause anorexia, tachypnea, lethargy, metabolic acidosis and death. Acetazolamide is linked with hypokalemia rather than hyperkalemia, and the other options are not described for this combination.
Before giving an osmotic diuretic, the nurse reviews the client's history. Which conditions are contraindications? Select all that apply.
- Increased intraocular pressure
- Anuria due to renal disease
- Pulmonary edema
- Severe dehydration
- Cerebral edema
Answer: Anuria due to renal disease, Pulmonary edema, Severe dehydration
Osmotic diuretics are contraindicated in anuria due to renal disease, pulmonary edema, severe dehydration and progressive heart failure. Cerebral edema and increased intraocular pressure are indications for mannitol, not contraindications.
A client's intracranial pressure is being monitored with a catheter and transducer. At what level does the section say therapy to lower the pressure should begin?
- Greater than 7 mm Hg
- Greater than 15 mm Hg
- Only when the client loses consciousness
- Greater than 20 mm Hg to 25 mm Hg
Answer: Greater than 20 mm Hg to 25 mm Hg
Therapy to lower intracranial pressure should start when it is greater than 20 to 25 mm Hg. Normal pressure is 7 to 15 mm Hg, so those values do not call for treatment, and waiting for loss of consciousness delays care.
Where every quote comes from
Section 12.3 Intracranial Emergencies and Intracranial Emergency Drugs of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.