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Pharmacology · chapter 19 · Heart Failure Drugs

Heart Failure

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. Preload, afterload, contractility

    Preload is the volume of blood returning to the heart, afterload is the amount of pressure that the left ventricle must push against, and contractility is the ability of the left ventricle to squeeze or pump blood.
  2. Ejection fraction

    Stroke volume is often measured by ejection fraction, or the percentage of blood that is pumped out of the left ventricle with each beat (Hajouli Ludhwani, 2022).
  3. What heart failure is

    Heart failure occurs when the heart is no longer able to generate an adequate cardiac output. Heart failure is a result of ventricular dysfunction; something has affected ventricular preload or contractility in such a way that the ventricle is no longer able to expel blood effectively (Malik et al., 2022).
  4. HFrEF: a contractility problem

    Heart failure with reduced ejection fraction is a problem stemming from inadequate contractility. It is the most common type of heart failure.
  5. Hypertension as a cause of HFrEF

    Hypertension is also a common cause of HFrEF. Long-standing untreated hypertension increases afterload and causes the left ventricle to work harder to eject blood.
  6. HFpEF: a stiff ventricle

    Heart failure with preserved ejection fraction stems from muscle stiffness. As people age, muscles can become stiff and not move as well as they did in younger years.
  7. Ejection fraction under 40%

    If a person has an ejection fraction of less than 40%, a diagnosis of heart failure with reduced ejection fraction is made.
  8. BNP and myocardial stretch

    One other blood test that is often included is a brain natriuretic peptide (BNP) to determine whether the heart is undergoing increased stretch. When cardiac myocytes are stretched too far, they release BNP (Novack Zevitz, 2022).
  9. Symptoms and a faster heart rate

    Symptoms associated with heart failure include shortness of breath, edema, exercise intolerance, and fatigue. Often people with heart failure have an increased heart rate due to the body’s compensatory mechanisms.
  10. Sodium restriction

    A sodium-restricted diet (less than 2000 mg of sodium per day) may help maintain euvolemia (normal blood volume) and prevent clients from becoming overloaded with fluid (which presents as pitting edema in the extremities, abdominal edema, and/or pulmonary edema).
  11. Potassium foods and salt substitutes

    Clients who take certain medications for heart failure (discussed later in this chapter) should be instructed to avoid foods high in potassium, such as bananas and watermelon, as well as salt substitutes because most substitute potassium for sodium.
  12. Tobacco and alcohol

    Clients should be encouraged to stop using any tobacco products and/or alcohol. Both can cause heart failure exacerbations.
  13. When to call the provider

    Clients should notify their health care provider if they gain 2–3 pounds in one day or 5 pounds in one week or if they notice increased swelling in their extremities, difficulty breathing, and/or chest pain.
  14. Orthostatic hypotension

    Other concerns: Heart failure drugs may cause orthostatic hypotension (a form of low blood pressure that occurs when going from a sitting or lying position to a standing position). The client should change positions slowly to prevent dizziness and fainting.

Terms to know

ejection fraction
Stroke volume is often measured by ejection fraction, or the percentage of blood that is pumped out of the left ventricle with each beat (Hajouli Ludhwani, 2022).
heart failure with reduced ejection fraction (HFrEF)
One is caused by a reduced ejection fraction and is called heart failure with reduced ejection fraction (HFrEF).
heart failure with preserved ejection fraction (HFpEF)
The other, called heart failure with preserved ejection fraction (HFpEF), occurs when the actual ejection fraction is not reduced but cardiac output is still decreased.
systolic heart failure
Because contractility and afterload are considered part of systole, this was traditionally referred to as systolic heart failure.
diastolic heart failure
Because preload is considered part of diastole (or ventricular filling), this type of heart failure traditionally was referred to as diastolic heart failure.
euvolemia
A sodium-restricted diet (less than 2000 mg of sodium per day) may help maintain euvolemia (normal blood volume) and prevent clients from becoming overloaded with fluid (which presents as pitting edema in the extremities, abdominal edema, and/or pulmonary edema).

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client with heart failure calls the clinic and reports that his weight went up 3 pounds since yesterday. His breathing is unchanged. What should the nurse tell him?

    1. This gain needs to be reported to the health care provider.
    2. Skip tomorrow's weigh-in to avoid worry.
    3. Increase fluid intake to flush out extra sodium.
    4. This is expected; weigh again next week.

    Answer: This gain needs to be reported to the health care provider.

    Clients with heart failure should notify the provider if they gain 2–3 pounds in one day or 5 pounds in one week, a sign of fluid overload. Waiting, skipping weights, or drinking more fluid ignores the warning sign.

  2. A nurse reviews a sodium-restricted diet with a client who has heart failure. Which food choice shows the client needs more teaching?

    1. Recording daily sodium intake
    2. Using a low-sodium recipe from the American Heart Association
    3. Canned soup for lunch
    4. Reading Nutrition Facts labels for sodium

    Answer: Canned soup for lunch

    Fast food, processed frozen meals, and canned foods all have very high sodium content, so canned soup needs more teaching. Reading labels, using low-sodium recipes, and recording sodium are all recommended.

  3. A nurse is assessing a client with suspected heart failure. Which findings are associated with heart failure? Select all that apply.

    1. Exercise intolerance
    2. Slow heart rate from compensation
    3. Edema
    4. Shortness of breath
    5. Fatigue

    Answer: Exercise intolerance, Edema, Shortness of breath, Fatigue

    Symptoms of heart failure include shortness of breath, edema, exercise intolerance, and fatigue. Compensation raises the heart rate rather than slowing it, because the body increases heart rate when stroke volume falls.

  4. A client asks why a brain natriuretic peptide (BNP) level was drawn for his heart. What is the nurse's best explanation?

    1. It shows whether the heart muscle is being stretched too far.
    2. It measures how much sodium is in the diet.
    3. It measures the heart's electrical rhythm.
    4. It checks kidney function only.

    Answer: It shows whether the heart muscle is being stretched too far.

    BNP is released when cardiac myocytes are stretched too far, so it shows whether the heart is under increased stretch. Rhythm is checked by an electrocardiogram and kidney function by the basic metabolic profile.

  5. A nurse is teaching a client who is going home on heart failure medications. Which statements by the client show understanding? Select all that apply.

    1. "I will get up slowly from the bed or chair."
    2. "If I miss a dose, I will take it when I remember unless it is almost time for the next one."
    3. "I can stop my medication once my ankles stop swelling."
    4. "If I miss a dose, I will take a double dose next time."
    5. "I will ask my provider or pharmacist before taking an herbal supplement."

    Answer: "I will get up slowly from the bed or chair.", "If I miss a dose, I will take it when I remember unless it is almost time for the next one.", "I will ask my provider or pharmacist before taking an herbal supplement."

    Heart failure drugs can cause orthostatic hypotension, so the client changes positions slowly; OTC drugs and herbal supplements need a provider or pharmacist's approval; and a missed dose is taken when remembered unless the next dose is near. Doubling doses and stopping abruptly are both on the list of things not to do.

  6. A client with heart failure has been told to avoid high-potassium foods because of one of his medications. He asks about using a salt substitute to cut sodium. What should the nurse say?

    1. Avoid most salt substitutes because they replace sodium with potassium.
    2. Salt substitutes are fine if you also eat bananas daily.
    3. Salt substitutes are the best way to reduce sodium.
    4. Use salt substitutes only with canned foods.

    Answer: Avoid most salt substitutes because they replace sodium with potassium.

    Clients on certain heart failure medications should avoid high-potassium foods such as bananas and watermelon, and salt substitutes, because most substitute potassium for sodium. The other answers add potassium or sodium the client should avoid.

Where every quote comes from

Section 19.1 Heart Failure of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.