Pharmacology · chapter 24 · Upper Respiratory Disorder Drugs
Expectorants and Mucolytics
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Expectorants only for productive coughs
Expectorants do not suppress the cough like antitussives do, so they should only be used with productive coughs when it is necessary to loosen and clear mucus.
How expectorants work
Expectorants work by lubricating the airways, stimulating the cough reflex, and decreasing mucus viscosity so that it is easier to expel (Cleveland Clinic, 2021).
How guaifenesin works
It increases production of respiratory tract fluids to help liquefy mucus and make it easier to expel.
Guaifenesin adverse effects
Guaifenesin does not cause many adverse effects, but dizziness, headache, nausea, and vomiting may occur.
Mucolytics for thick mucus
They differ from expectorants in that they are used to help high-risk respiratory clients cough up thick, tenacious mucus. Mucolytics directly break down the structure of mucus by breaking its protein bonds, helping to reduce the thickness and stickiness of mucus.
Tracheostomy and bronchoscopy
Clients with tracheostomies often benefit from mucolytics. Mucolytics are also sometimes used to clear the airway in preparation for a bronchoscopy.
Acetylcysteine uses
Acetylcysteine is used to help clients clear thick, tenacious mucus from the airways. It is often used in clients with pneumonia, bronchitis, cystic fibrosis, and emphysema.
Acetylcysteine as an antidote
To manage respiratory symptoms, the medication is inhaled. Acetylcysteine is also administered orally or intravenously as the antidote for acetaminophen toxicity.
Acetylcysteine side effects and contraindications
Side effects include tachycardia, nausea, and vomiting. Acetylcysteine is contraindicated in clients with hypersensitivity to it or those with peptic ulcer disease.
Dornase alfa in cystic fibrosis
Dornase alfa is another mucolytic used most often to lower the number of lung infections and help lung function in cystic fibrosis.
Dornase alfa adverse effects
Dornase alfa can cause voice changes, hoarseness, and sore throat.
Vomiting risk with acetylcysteine
Because acetylcysteine commonly causes vomiting, it should be strictly avoided in clients with peptic ulcer disease, esophageal varices, and Mallory-Weis tears.
Bronchospasm in clients with asthma
Clients receiving acetylcysteine should be monitored closely for bronchospasm, especially if they have asthma, because they are at higher risk for bronchospasm.
Fluids and deep breathing
Be sure to drink fluids to help loosen secretions. Increase deep breathing exercises to assist with secretion movement.
Terms to know
- Expectorants
- Expectorants are a class of drugs that help to clear mucus from the airways when coughing.
- Mucolytics
- Mucolytics also help clients to clear mucus from the airway.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client with asthma is receiving inhaled acetylcysteine. Which finding requires the nurse's immediate attention?
- New wheezing and shortness of breath
- Thinner sputum
- Coughing up more mucus
- A mild headache
Answer: New wheezing and shortness of breath
Clients receiving acetylcysteine, especially those with asthma, are monitored closely for bronchospasm, so new wheezing and dyspnea need immediate action. Thinner sputum and more productive coughing are the intended effect.
A client with a history of esophageal varices has an order for acetylcysteine for thick secretions. What should the nurse do?
- Give it with food to prevent all side effects.
- Give it; it has no gastrointestinal effects.
- Clarify the order because acetylcysteine commonly causes vomiting.
- Double the dose to shorten therapy.
Answer: Clarify the order because acetylcysteine commonly causes vomiting.
Acetylcysteine commonly causes vomiting and should be strictly avoided in clients with peptic ulcer disease, esophageal varices, and Mallory-Weiss tears. Giving it with food or at a higher dose does not remove the risk.
A client with a dry, nonproductive cough asks whether to buy guaifenesin. What should the nurse explain?
- Expectorants are used for productive coughs to loosen and clear mucus.
- Guaifenesin works only in cystic fibrosis.
- Guaifenesin suppresses dry coughs very well.
- Guaifenesin requires a prescription.
Answer: Expectorants are used for productive coughs to loosen and clear mucus.
Expectorants do not suppress the cough and should only be used with productive coughs to loosen and clear mucus. Guaifenesin is available over the counter and is not limited to cystic fibrosis.
A nurse is teaching a client who is taking an expectorant. Which instructions should be included? Select all that apply.
- Take the drug only for the time indicated.
- Report symptoms that last longer than one week.
- Increase deep breathing exercises.
- Drink fluids to help loosen secretions.
- Limit fluids so the mucus stays thick.
Answer: Take the drug only for the time indicated., Report symptoms that last longer than one week., Increase deep breathing exercises., Drink fluids to help loosen secretions.
Clients drink fluids, increase deep breathing, take the drug only as prescribed, and report symptoms lasting longer than a week. Limiting fluids works against loosening secretions.
In which situations might the nurse expect a mucolytic to be ordered? Select all that apply.
- Cystic fibrosis with thick, sticky mucus
- Acetaminophen toxicity
- Preparation for a bronchoscopy
- Routine tracheostomy care
- A dry cough from allergies
Answer: Cystic fibrosis with thick, sticky mucus, Acetaminophen toxicity, Preparation for a bronchoscopy, Routine tracheostomy care
Mucolytics help clients with tracheostomies, clear the airway before bronchoscopy, and thin mucus in cystic fibrosis, and acetylcysteine is also the antidote for acetaminophen toxicity. A dry allergic cough does not call for thinning mucus.
A client with cystic fibrosis asks how dornase alfa helps. Which response is accurate?
- It suppresses the cough reflex in the medulla.
- It kills bacteria directly.
- It opens the airways like a bronchodilator.
- It thins thick, sticky mucus, which lowers the number of lung infections.
Answer: It thins thick, sticky mucus, which lowers the number of lung infections.
Dornase alfa acts like a natural lung enzyme to thin thick, sticky mucus; removing mucus reduces the breeding ground for bacteria and so the number of infections. It is not a cough suppressant, antibiotic, or bronchodilator.
Where every quote comes from
Section 24.3 Expectorants and Mucolytics of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.