Pharmacology · chapter 2 · Drug Administration
Drug Administration Routes, Preparation, and Administration
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
One-client preparation
It is best practice to prepare medications for only one client at a time. This safety practice reduces the risk of inadvertently administering medications to the incorrect client.
Focused assessment before drugs
Medications that require a focused assessment or monitoring should be kept separate from other medications. For example, if administering a medication that lowers blood pressure and heart rate, vital signs should be assessed before giving the drug.
Opioid respiratory monitoring
Because opioids may cause respiratory depression, respiratory rate and oxygen saturation should be assessed before and after administration of the drug.
Bedside medication opening
All unit-dose medications should be opened at the bedside rather than in the medication room. Never leave medications unattended at the bedside unless specifically ordered.
Package insert contents
Some of the information contained in the inserts includes generic and trade names, routes, instructions for taking the drug, and how to store and dispose of the drug.
Oral route limitations
Oral administration is usually quick, easy, and convenient, but the onset of action is longer and unpredictable due to the first-pass effect, and not all drugs can be administered this way.
Timed-release oral safety
Timed-release capsules or tablets should not be crushed or chewed because this may affect the rate of absorption and toxicity may occur.
Sublingual buccal absorption
These are vascular areas, and medications administered here are absorbed rapidly because they do not undergo the first-pass effect.
Sublingual buccal instructions
Discuss the importance of not swallowing or chewing the pill. Educate the client about the importance of abstaining from food, drinking, or smoking until after the medication has dissolved.
Nasal spray sneezing
Do not readminister the drug if the client sneezes following the administration of the nasal spray because there is no way to assess how much of the drug has been absorbed.
Parenteral sterility
The nurse should be very alert during the process of drawing up and administering the medication to keep the needle and contents sterile.
Filter needle warning
Never inject a medication into a client using a filter needle. A filter needle is used to remove any microscopic glass particles that might occur as a result of ampule breakage.
Subcutaneous absorption
Medication administered here is often absorbed slowly due to the reduced number of blood vessels in this area.
Subcutaneous site care
Routine injections should be rotated regularly among the different sites. Do not inject into sites that are hard when palpated.
Terms to know
- Enteral administration
- Enteral administration: “Enteral” means “pertaining to the intestines.”
- Parenteral administration
- Parenteral administration: “Parenteral” refers to any drug that is administered outside of the GI tract; however, it most commonly refers to injectable drugs administered via the subcutaneous, intramuscular, or intravenous routes.
- NPO
- NPO is a Latin term meaning nil per os, or nothing by mouth.
- Subcutaneous injections
- Subcutaneous injections are administered “under the skin” into the adipose tissue between the dermis and muscular layer.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client is prescribed an opioid analgesic. Which nursing action is the priority related to safe administration?
- Open the unit-dose medication in the medication room before entering the client’s room.
- Assess the respiratory rate and oxygen saturation before and after administration.
- Assess only the client’s blood pressure before administration.
- Leave the medication at the bedside so the client can take it when pain increases.
Answer: Assess the respiratory rate and oxygen saturation before and after administration.
Opioids may cause respiratory depression, so respiratory status must be assessed before and after giving the drug. The other actions either assess the wrong parameter, create a medication safety risk, or conflict with bedside administration guidance.
The nurse is preparing to administer oral tablets to a client. Which actions follow the section’s procedure? Select all that apply.
- Assess swallowing ability and gag reflex by offering a sip of water.
- Position the client upright or on the side as the condition allows.
- Ask whether the client prefers all medications at once or one or two at a time.
- Crush all tablets together if the client says swallowing is difficult.
- Give the medication with approximately 8 ounces of water unless the client has a fluid restriction.
Answer: Assess swallowing ability and gag reflex by offering a sip of water., Position the client upright or on the side as the condition allows., Ask whether the client prefers all medications at once or one or two at a time., Give the medication with approximately 8 ounces of water unless the client has a fluid restriction.
The section directs the nurse to position the client safely, assess swallowing and gag reflex, ask about preferred pacing, and provide water unless restricted. Crushing all tablets together is unsafe because some tablets should not be crushed and crushed tablets should be kept separate.
A client has difficulty swallowing and asks the nurse to crush a timed-release tablet into applesauce. What is the best response by the nurse?
- Tell the client to chew the tablet slowly to improve swallowing.
- Do not crush or chew the tablet; consult a pharmacist for an appropriate administration technique.
- Split the tablet even if it is not scored so the pieces are smaller.
- Crush the tablet and mix it with food because the client cannot swallow it whole.
Answer: Do not crush or chew the tablet; consult a pharmacist for an appropriate administration technique.
Timed-release tablets should not be crushed or chewed because doing so can change absorption and may cause toxicity. When a client has difficulty swallowing a tablet or capsule, the nurse should consult a pharmacist for guidance.
The nurse is teaching a client how to take a sublingual or buccal medication. Which instructions are appropriate? Select all that apply.
- Chew the medication and drink water immediately to help it work faster.
- Moisten the oral cavity with sips of water before placing the medication.
- Do not swallow or chew the pill, and avoid food, drinking, or smoking until it dissolves.
- Allow the medication to dissolve completely.
- Place a sublingual medication under the tongue or a buccal medication between the cheek and gum.
Answer: Moisten the oral cavity with sips of water before placing the medication., Do not swallow or chew the pill, and avoid food, drinking, or smoking until it dissolves., Allow the medication to dissolve completely., Place a sublingual medication under the tongue or a buccal medication between the cheek and gum.
Sublingual and buccal medications are placed in the mouth to dissolve and be absorbed through vascular oral tissue. Swallowing, chewing, eating, drinking, or smoking before the medication dissolves conflicts with the administration instructions.
Immediately after receiving a nasal spray, a client sneezes and asks the nurse for another spray. What should the nurse do?
- Do not readminister the nasal spray.
- Have the client blow the nose immediately and then repeat the dose.
- Repeat the dose in the same nostril immediately.
- Repeat the dose only if the client reports no burning or stinging.
Answer: Do not readminister the nasal spray.
The nurse should not give another dose after sneezing because the amount already absorbed cannot be determined. Repeating the spray could result in giving more medication than intended, and the client should avoid blowing the nose immediately after administration.
A nurse is teaching a client about routine subcutaneous injections. Which instructions are consistent with the section? Select all that apply.
- Use a site that feels hard when palpated if it is easy to reach.
- Check the drug’s package insert or labeling for the specific injection sites.
- Gentle pressure may be applied after the drug has been administered.
- Rotate routine injections regularly among different sites.
- Do not rub the injection site after administration.
Answer: Check the drug’s package insert or labeling for the specific injection sites., Gentle pressure may be applied after the drug has been administered., Rotate routine injections regularly among different sites., Do not rub the injection site after administration.
The section states that specific sites are usually found in the package insert or labeling, routine injections should be rotated, and hard sites should be avoided. The site should not be rubbed after injection, although gentle pressure may be used.
Where every quote comes from
Section 2.3 Drug Administration Routes, Preparation, and Administration of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.