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Pharmacology · chapter 17 · Antidysrhythmic Drugs

Class II: Beta Adrenergic Blockers

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.

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Key points

  1. How to recognise the class

    Beta-adrenergic blockers (informally called beta blocker s) are known by their generic names, which end with “olol.” They can be used for many disease states, including heart failure, myocardial infarction, angina, and hypertension.
  2. What they do to the heart

    Beta-adrenergic blockers block adrenergic beta-1 receptors in the heart (among other actions, depending on the drug), which leads to decreased heart rate from the SA node. It also leads to a decreased rate of conduction through the AV node and decreased cardiac contractility.
  3. Beta-2 receptors in the lungs

    There are other types of beta-adrenergic receptors, such as beta-2 receptors in the lungs that mediate bronchoconstriction.
  4. Never stop them suddenly

    Clients should avoid stopping beta-adrenergic blockers abruptly because sudden discontinuation can exacerbate arrhythmias.
  5. Check the heart rate first

    Beta-adrenergic blockers can cause bradycardia. The nurse should monitor the client’s heart rate before administration and not give the drug to bradycardic clients who do not have a functioning pacemaker.
  6. Esmolol acts fast and wears off fast

    Esmolol is very fast acting and slows the heart rate within 2–10 min of administration. It also has a short duration; the half-life of esmolol in adults is only 9 min.
  7. Esmolol is a vesicant

    Esmolol is a vesicant, and extravasation can lead to skin necrosis and sloughing. The nurse should ensure proper needle/catheter placement.
  8. Two forms of metoprolol

    It is available as an immediate-release tablet (metoprolol tartrate) and an extended-release tablet (metoprolol succinate). It is also available in an intravenous form.
  9. Hypotension without direct vasodilation

    Cardioselective beta-adrenergic blockers do not have direct hypotensive effects on the vasculature but can still cause hypotension through decreased cardiac output.
  10. Masked hypoglycemia

    Beta-adrenergic blockers can mask hypoglycemia due to their effects on heart rate, so clients with diabetes should be aware that they will not necessarily experience their typical hypoglycemic symptoms.
  11. Fatigue, bronchospasm and sexual effects

    Beta-adrenergic blockers can cause central nervous system adverse effects, especially fatigue. They also can be associated with bronchospasm; however, cardioselective beta-adrenergic blockers have a lower risk for this.
  12. Starting too fast can worsen heart failure

    Although beta-adrenergic blockers are indicated to treat heart failure long term, starting beta-adrenergic blockers too quickly or at too high a dose can lead to heart failure exacerbations because of their effect on cardiac contractility.
  13. Contraindications

    Beta-adrenergic blockers can cause bradycardia and are contraindicated in clients who have severe bradycardia unless they have a pacemaker and in clients in cardiogenic shock.
  14. Heart rate below 60

    If the baseline heart rate is less than 60 beats per minute, consider checking with the health care provider before giving the drug.

Terms to know

Esmolol
Esmolol is an intravenous beta-adrenergic blocker that is selective for the beta-1 receptors in the heart.
Metoprolol
Metoprolol is a beta-adrenergic blocker with selective activity at beta-1 receptors in the heart.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

The graded version needs JavaScript. Every question is below anyway, with the answer and why.

Every question here, with the answer

  1. A client with atrial fibrillation is due for oral metoprolol. The nurse finds an apical heart rate of 52 beats per minute. The client has no pacemaker. What should the nurse do?

    1. Hold the dose and check with the health care provider.
    2. Give the dose with food to slow absorption.
    3. Give half the dose to reduce the effect on heart rate.
    4. Give the dose and recheck the heart rate in one hour.

    Answer: Hold the dose and check with the health care provider.

    Beta blockers slow the heart rate and can cause bradycardia. With a baseline heart rate under 60 and no pacemaker, the nurse checks with the provider before giving the drug. Giving all or part of the dose, or changing how it is absorbed, still lowers an already slow rate.

  2. A client with type 2 diabetes is starting metoprolol. Which teaching point is most important for this client?

    1. Metoprolol protects you from hypoglycemia.
    2. Metoprolol will lower your blood glucose, so reduce your diabetes medication.
    3. Take metoprolol only on days your blood glucose is high.
    4. The usual warning signs of low blood sugar, like a racing heart, may not show up.

    Answer: The usual warning signs of low blood sugar, like a racing heart, may not show up.

    Beta blockers can mask hypoglycemia because they blunt the heart-rate response, so a client with diabetes may not feel the typical warning symptoms. The other options invent effects the drug does not have or suggest skipping doses.

  3. A nurse is teaching a client who is going home on a beta-adrenergic blocker. Which instructions should the nurse include? Select all that apply.

    1. Double the next dose if you miss one.
    2. Stop the medication if you feel tired.
    3. Stand up slowly from sitting or lying down.
    4. Do not stop the medication suddenly.
    5. Call the health care provider if you feel very dizzy.

    Answer: Stand up slowly from sitting or lying down., Do not stop the medication suddenly., Call the health care provider if you feel very dizzy.

    The client should move slowly to avoid orthostatic hypotension, never stop abruptly because that can cause arrhythmias and withdrawal effects, and report marked dizziness. Stopping for fatigue is abrupt discontinuation, and doubling a dose is not in the teaching.

  4. An esmolol infusion is running through a peripheral IV. The nurse notices swelling and coolness at the insertion site. What is the nurse's first action?

    1. Slow the infusion rate by half.
    2. Apply a warm compress and continue the infusion.
    3. Stop the infusion.
    4. Flush the line to check patency.

    Answer: Stop the infusion.

    Esmolol is a vesicant, and extravasation can cause skin necrosis. When extravasation occurs, the infusion is stopped first, then the line aspirated and the limb elevated. Slowing, continuing or flushing pushes more drug into the tissue.

  5. Which conditions are contraindications or reasons for caution with beta-adrenergic blockers? Select all that apply.

    1. Cardiogenic shock
    2. Controlled hypertension
    3. Acute exacerbation of heart failure
    4. Stable angina
    5. Severe bradycardia without a pacemaker

    Answer: Cardiogenic shock, Acute exacerbation of heart failure, Severe bradycardia without a pacemaker

    Beta blockers are contraindicated in severe bradycardia without a pacemaker and in cardiogenic shock, and should be used cautiously in acute heart failure exacerbations. Hypertension and angina are conditions they are used to treat.

  6. A client asks why the health care provider started metoprolol at a low dose for heart failure instead of the full dose. Which response is accurate?

    1. Low doses work better than high doses for heart failure.
    2. The full dose is only used for high blood pressure.
    3. A low dose prevents the drug from lowering the heart rate.
    4. Starting too quickly or too high can make heart failure worse, because the drug reduces how hard the heart contracts.

    Answer: Starting too quickly or too high can make heart failure worse, because the drug reduces how hard the heart contracts.

    Beta blockers treat heart failure long term, but because they decrease contractility, starting too fast or too high can cause a heart failure exacerbation. The other statements are not supported by the section.

Where every quote comes from

Section 17.3 Class II: Beta Adrenergic Blockers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.