Pharmacology · chapter 30 · Gastrointestinal Disorder Drugs
Antiemetics
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
Treat the cause, not only the vomiting
When administering an antiemetic, the health care provider should identify the factors causing nausea and vomiting. Treatment or elimination of the causative factors should be a goal of antiemetic treatment.
Phenothiazines and falls
Additionally, phenothiazines interact with alpha adrenergic, serotonergic, histaminic, and muscarinic receptors, potentially causing orthostatic hypotension and sedation. Prioritizing fall precautions is essential in the nursing plan of care when administering these drugs.
Chlorpromazine and extrapyramidal symptoms
However, its dopamine receptor blockade can lead to extrapyramidal symptoms, making it less commonly used for nausea and vomiting compared to promethazine and prochlorperazine.
Black box: older adults with dementia
Increased mortality can occur when taking chlorpromazine and prochlorperazine in older adults with dementia-related psychosis.
Black box: promethazine under age 2
Severe respiratory depression and death in pediatric clients under age 2 may occur with promethazine.
Hydroxyzine injection site
When using the injectable form of hydroxyzine to treat nausea and vomiting, it should be administered deep into a large muscle, such as the gluteus maximus for adult clients and the vastus lateralis (the muscle on the outside of the thigh) for pediatric clients.
Ondansetron uses
Ondansetron is one of the most effective antiemetics used to treat postoperative nausea and vomiting as well as nausea and vomiting associated with chemotherapy and radiation therapy.
NK1 antagonists work best in combination
As substance P coexists with serotonin in the body, the NK 1 antagonist works best when concurrently used in combination with a serotonin antagonist and glucocorticoid.
Scopolamine patch timing
Scopolamine transdermal patch is generally administered 4 hours before traveling in clients who suffer from motion sickness and in clients with post-anesthesia nausea and vomiting.
Applying the scopolamine patch
Application of the transdermal patch is best to the hairless area behind the ear, after the area is cleansed and dried to ensure adherence. Nurses should wear gloves during application to avoid accidental cross-absorption and should educate clients not to touch the patch.
Removing the scopolamine patch
When removing the transdermal patch, nurses should wear gloves and fold the patch in half so that the adhesive sides stick together for disposal, following facility policy.
Typical adverse effects
Typical adverse effects of common antiemetics include drowsiness, fatigue, dry mouth, constipation, headache, and dizziness.
Other CNS depressants
Antiemetics should be used cautiously or avoided when used concomittantly with other CNS depressants, as this may cause increased risk for CNS effects such as enhanced sedation, respiratory depression, and impaired cognitive function.
Report low blood pressure
Monitor blood pressure and report systolic blood pressure less than 90 mmHg and diastolic pressure less than 60 mmHg to the health care provider as this may represent hypotension.
Terms to know
- Antiemetics
- Antiemetics are a group of drugs that manage nausea and vomiting.
- Phenothiazines
- Phenothiazines are a class of drugs that produce antiemetic, antipsychotic, antihistaminic, and anticholinergic effects, primarily acting centrally to alleviate mild to moderate nausea and vomiting resulting from anesthesia, surgery, radiation, or chemotherapy.
- Substance P
- Substance P is a neurotransmitter found in high concentrations in the central and peripheral nervous systems that plays a vital role in pain modulation and may influence vomiting via the neurokinin-1 (NK 1) receptors.
- Dronabinol
- Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (THC) that manages chemotherapy-induced nausea and vomiting (CINV) by activating cannabinoid receptors in the brain.
- Anticholinergics
- Anticholinergics, also called cholinergic antagonists, are drugs that block the actions of acetylcholine.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
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Every question here, with the answer
A nurse is applying a scopolamine patch for a client who gets motion sickness. Which action is correct?
- Apply it just as the client boards the boat.
- Apply it to the chest without gloves so it sticks better.
- Apply it to the hairless area behind the ear while wearing gloves.
- Cut the patch in half to reduce the dose.
Answer: Apply it to the hairless area behind the ear while wearing gloves.
The patch goes on the clean, dry, hairless area behind the ear, and the nurse wears gloves to avoid cross-absorption. It is applied about 4 hours before travel, not at departure.
A parent asks whether promethazine can be given to an 18-month-old with vomiting. What should the nurse recognise?
- It is only unsafe in older adults.
- It is safe if given rectally.
- It is safe at a reduced dose.
- It carries a warning of severe respiratory depression and death in children under age 2.
Answer: It carries a warning of severe respiratory depression and death in children under age 2.
The black box warning states that severe respiratory depression and death may occur with promethazine in pediatric clients under age 2. No dose or route change makes it safe for this child.
A client receiving chlorpromazine develops involuntary facial movements and muscle spasms of the neck. What should the nurse do?
- Document it as an expected effect.
- Give the next dose early.
- Encourage the client to exercise the neck.
- Report it to the health care provider immediately.
Answer: Report it to the health care provider immediately.
Chlorpromazine can cause extrapyramidal symptoms such as dystonia and tardive dyskinesia, and the nurse reports these to the health care provider immediately. They are not expected side effects to simply document or to treat with more drug.
A client is receiving prochlorperazine for nausea. Which nursing actions are appropriate? Select all that apply.
- Initiate fall precautions.
- Monitor intake and output for urinary retention.
- Tell the client it is safe to drive right after the dose.
- Encourage the client to drink alcohol to relax.
- Monitor blood pressure for hypotension.
Answer: Initiate fall precautions., Monitor intake and output for urinary retention., Monitor blood pressure for hypotension.
Antiemetics can cause orthostatic hypotension, dizziness and urinary retention, so the nurse initiates fall precautions and monitors blood pressure and output. Alcohol adds CNS depression, and clients should not drive because of drowsiness.
The nurse is teaching a client going home with an antiemetic. Which instructions should be included? Select all that apply.
- Increase fiber and fluids if not contraindicated.
- Use sugarless candy or gum for dry mouth.
- Stop drinking fluids to reduce nausea.
- Rise slowly from lying or sitting.
- Take the drug with a sleeping pill to improve rest.
Answer: Increase fiber and fluids if not contraindicated., Use sugarless candy or gum for dry mouth., Rise slowly from lying or sitting.
Teaching covers dry mouth relief, fiber and fluids to prevent constipation, and rising slowly because of orthostatic hypotension. Combining with other CNS depressants increases sedation and respiratory depression, and fluids should be increased, not stopped.
An older adult with dementia-related psychosis has an order for prochlorperazine for nausea. What should concern the nurse?
- Risk of hyperglycemia
- Increased mortality in this population
- Risk of weight gain
- Loss of effect after one dose
Answer: Increased mortality in this population
The black box warning states increased mortality can occur with chlorpromazine and prochlorperazine in older adults with dementia-related psychosis. The other options are not warnings given for these drugs.
Where every quote comes from
Section 30.1 Antiemetics of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.