Pharmacology · chapter 15 · Substance Use Disorder Treatment Drugs
Alcohol Use Disorder Drugs
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
How alcohol acts on GABA
Alcohol works by increasing the actions of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain.
Alcohol with other CNS depressants
The risk for respiratory depression and death increases significantly if consumed along with other CNS depressants (e.g., opioids, benzodiazepines).
Vomiting and aspiration risk
If the client is sufficiently CNS depressed and vomits, there is a risk for the client to aspirate their stomach contents, leading to respiratory failure and death.
Signs of alcohol withdrawal
This leads to the opposite actions of alcohol where clients may develop anxiety, restlessness, piloerection, hallucinations, and seizures.
Timing of alcohol withdrawal
Withdrawal from alcohol may begin as soon as a few hours after the last consumption of alcohol but may take 2–3 days to fully manifest.
Alcohol withdrawal can be fatal
As compared to the minimal risk of death seen with opioid withdrawal, alcohol withdrawal can be fatal and should be managed promptly to avoid withdrawal-related delirium and seizures.
Benzodiazepines replace alcohol
Benzodiazepines are used for a variety of conditions, including anxiety and seizures, but in the case of AUD, they serve as a replacement for alcohol to treat and/or prevent withdrawal symptoms.
Chlordiazepoxide can accumulate
The downside of chlordiazepoxide’s long half-life is that it tends to accumulate in the client’s body, leading to oversedation, especially when combined with alcohol should the client relapse during treatment.
Disulfiram is a deterrent
Disulfiram is used to intentionally inhibit acetaldehyde dehydrogenase to cause a client to develop this uncomfortable reaction should they relapse and consume alcohol. In this way, it serves as a deterrent to alcohol consumption rather than a means to replace alcohol to manage withdrawal symptoms.
Disulfiram timing before and after
To initiate disulfiram therapy, clients should abstain from alcohol for at least 12 hours since their last drink to avoid a flushing reaction. Clients should also be educated that disulfiram reactions can occur up to 2 weeks after drug discontinuation and that they should avoid alcohol consumption during this time to avoid flushing reactions.
Lorazepam for withdrawal seizures
Replacement of alcohol with lorazepam helps prevent and/or minimize withdrawal symptoms, and it is the drug of choice to treat alcohol withdrawal-induced seizures.
CIWA-Ar scores recorded by the nurse
These scores are recorded by the client’s nurse initially every 4 hours and can be checked less frequently as the client’s withdrawal symptoms improve.
Haloperidol lowers the seizure threshold
Haloperidol can lower the seizure threshold, which increases the risk of the client developing alcohol withdrawal-related seizures. Because of this, haloperidol is not routinely recommended for this indication.
Hidden sources of alcohol
Avoid consuming nontraditional sources of alcohol, including mouthwashes, cough syrups, hand sanitizers, and any other product that contains alcohol.
Terms to know
- delirium tremens
- Severe alcohol withdrawal is commonly referred to as delirium tremens.
- Alcohol withdrawal
- Alcohol withdrawal occurs when the client who chronically uses alcohol has an abrupt discontinuation of the substance.
- Disulfiram
- Disulfiram is a drug that works by inhibiting the actions of the enzyme acetaldehyde dehydrogenase.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
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A client admitted for surgery drinks heavily every day. Twenty hours after the last drink, the client is anxious, restless and seeing things that are not there. What is the nurse's priority concern?
- Opioid withdrawal
- Normal postoperative anxiety
- Alcohol intoxication
- Alcohol withdrawal, which can progress to seizures and can be fatal
Answer: Alcohol withdrawal, which can progress to seizures and can be fatal
Anxiety, restlessness and hallucinations after stopping chronic alcohol use are signs of alcohol withdrawal, which can be fatal and must be managed promptly. The client has not been drinking, so this is not intoxication, and it is not simple postoperative anxiety.
A client in alcohol withdrawal has a seizure on the unit. Which drug does the nurse expect to give?
- Lorazepam
- Metronidazole
- Haloperidol
- Disulfiram
Answer: Lorazepam
Lorazepam is the drug of choice for alcohol withdrawal-induced seizures. Haloperidol lowers the seizure threshold, and disulfiram is a deterrent that does not treat withdrawal.
A client is starting disulfiram. Which products should the nurse teach the client to avoid? Select all that apply.
- Plain water
- Beer
- Alcohol-based hand sanitizer
- Mouthwash containing alcohol
- Cough syrup containing alcohol
Answer: Beer, Alcohol-based hand sanitizer, Mouthwash containing alcohol, Cough syrup containing alcohol
Even small amounts of alcohol, including mouthwashes, cough syrups and hand sanitizers, can cause a disulfiram reaction, as can alcoholic drinks. Water contains no alcohol.
A client asks whether it is safe to have a drink one week after stopping disulfiram. What is the nurse's best response?
- Yes, as long as you drink with food.
- No, you can never drink alcohol again after taking disulfiram.
- Yes, disulfiram leaves the body within a day.
- No, a reaction can still occur up to 2 weeks after stopping disulfiram.
Answer: No, a reaction can still occur up to 2 weeks after stopping disulfiram.
Disulfiram reactions can occur up to 2 weeks after the drug is stopped, so alcohol should be avoided for that period. There is no lifelong ban in the section, and food does not prevent the reaction.
A client is receiving chlordiazepoxide for alcohol withdrawal. Which nursing actions are appropriate? Select all that apply.
- Advise the client not to combine the drug with alcohol or opioids.
- Keep seizure rescue medication available.
- Assess for oversedation.
- Encourage the client to drink small amounts of alcohol to ease withdrawal.
- Teach the client not to operate heavy machinery.
Answer: Advise the client not to combine the drug with alcohol or opioids., Keep seizure rescue medication available., Assess for oversedation., Teach the client not to operate heavy machinery.
Chlordiazepoxide can accumulate and oversedate, causes sedation and memory impairment, and combining it with other CNS depressants raises the risk of respiratory depression; clients with significant AUD should be monitored for seizures with rescue drugs available. Drinking alcohol with it increases oversedation.
A family member asks the nurse to secretly put disulfiram in a client's coffee to stop them drinking. What is the nurse's best response?
- Agree, as long as the dose is small.
- Suggest giving it only when the client is intoxicated.
- Explain that disulfiram must never be given without the client's full knowledge.
- Recommend mixing it with orange juice instead.
Answer: Explain that disulfiram must never be given without the client's full knowledge.
Disulfiram should never be given to a client who is intoxicated or without their full knowledge, and the provider should instruct relatives of this. Hiding it in any drink or giving it during intoxication breaks this warning.
Where every quote comes from
Section 15.3 Alcohol Use Disorder Drugs of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.