Pharmacology · chapter 19 · Heart Failure Drugs
Adjunct Medications Used in Heart Failure
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
When hydralazine/isosorbide dinitrate is used
Hydralazine and isosorbide dinitrate (BiDil) are administered as a combination drug in clients with heart failure who have optimized therapy with other medications but still have a low ejection fraction and/or symptoms.
Mortality benefit in Black clients
This drug combination has been shown to reduce mortality in Black clients with heart failure (Heidenreich et al., 2022).
Vasodilation lowers afterload
The combination of hydralazine and isosorbide dinitrate causes vasodilation, which decreases afterload, or the amount of force that the heart must pump against. Hydralazine directly vasodilates arterioles.
Never with PDE5 inhibitors
Contraindications include allergy to nitrates and use with phosphodiesterase type 5 (PDE5) inhibitors.
Hold if systolic pressure is under 90
Monitor the client’s blood pressure when initiating hydralazine/isosorbide dinitrate, and do not administer the medication if systolic blood pressure is less than 90 mm Hg.
Get up slowly at first
Get up slowly during the first couple of days of taking the medication in case of orthostatic hypotension.
Digoxin strengthens contraction
If there is more calcium, then the force of contraction is stronger. Because of this, digoxin is referred to as a positive inotrope.
Digoxin slows the heart
Digoxin also stimulates the parasympathetic nervous system, which affects the electrical conduction system of the heart. Parasympathetic stimulation causes the heart to beat less often.
Narrow therapeutic index and toxicity signs
Digoxin has a narrow therapeutic index and a high potential for toxicity. Signs and symptoms of digoxin toxicity include anorexia, nausea, vomiting, visual changes, and cardiac arrhythmias.
Digoxin contraindications
Contraindications include acute myocardial infarction, ventricular fibrillation, Wolff-Parkinson-White syndrome, myocarditis, hypokalemia, and hypomagnesemia.
Apical pulse before digoxin
Nursing Implications The nurse should do the following for clients who are taking digoxin: Assess pulse for 1 minute prior to administering digoxin. If heart rate is less than 60 beats per minute, do not administer the dose.
Monitor digoxin and potassium levels
Monitor serum digoxin levels and for signs and symptoms of digoxin toxicity. Also monitor serum potassium levels.
Ivabradine slows the heart rate
Ivabradine is an I f current inhibitor that affects the cardiac pacemaker current (I f) directly, causing a decreased heart rate and longer diastole.
Ivabradine teaching: food and grapefruit
Inform clients that ivabradine must be taken with food. Teach clients about food and drug interactions.
Terms to know
- afterload
- The combination of hydralazine and isosorbide dinitrate causes vasodilation, which decreases afterload, or the amount of force that the heart must pump against.
- positive inotrope
- Because of this, digoxin is referred to as a positive inotrope.
- Ivabradine
- Ivabradine is an I f current inhibitor that affects the cardiac pacemaker current (I f) directly, causing a decreased heart rate and longer diastole.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A nurse is about to give digoxin to a client with heart failure. The apical pulse, counted for 1 full minute, is 54 beats per minute. What should the nurse do?
- Give the dose and recheck the pulse in one hour.
- Hold the dose.
- Give half the dose.
- Recount the pulse for 15 seconds and give the dose if it is higher.
Answer: Hold the dose.
The pulse is assessed for 1 minute before digoxin, and the dose is not given if the heart rate is under 60 beats per minute. Giving all or part of the dose, or recounting over a shorter period to justify giving it, ignores that rule.
A client taking digoxin calls the clinic. Which reported symptoms suggest digoxin toxicity? Select all that apply.
- Nausea and vomiting
- Weight gain of 1 pound over a month
- Yellow or green halos around lights
- Increased appetite
- Loss of appetite
Answer: Nausea and vomiting, Yellow or green halos around lights, Loss of appetite
Anorexia, nausea, vomiting and visual changes such as green or yellow halos around lights are signs of digoxin toxicity, and the client should contact the provider immediately. Increased appetite and slight weight gain are not listed.
A client with heart failure who takes hydralazine/isosorbide dinitrate asks whether he can use a prescribed erectile dysfunction medication. What is the nurse's best response?
- "No. Taking them together can cause profound hypotension."
- "Yes, but only at half the usual dose."
- "Yes, they do not interact."
- "Yes, as long as you take them at different times of day."
Answer: "No. Taking them together can cause profound hypotension."
This combination should not be taken with PDE5 inhibitors because it can lead to profound hypotension, and clients are taught not to take erectile dysfunction medications with it. Spacing or halving the dose is not supported by the section.
A client is due for the first dose of hydralazine/isosorbide dinitrate. The blood pressure is 86/54 mm Hg. What should the nurse do?
- Withhold the dose and notify the provider.
- Give the dose and have the client stay in bed.
- Give only the hydralazine part of the dose.
- Give the dose with extra fluids.
Answer: Withhold the dose and notify the provider.
The medication is not given if the systolic blood pressure is less than 90 mm Hg, because the combination can cause significant hypotension. The other options still give a drug that lowers blood pressure further.
A nurse reviews the chart of a client prescribed digoxin. Which findings are contraindications the nurse should report? Select all that apply.
- Hypokalemia
- Acute myocardial infarction
- Reduced ejection fraction with symptoms despite optimized therapy
- Hypomagnesemia
- Heart failure
Answer: Hypokalemia, Acute myocardial infarction, Hypomagnesemia
Hypokalemia, hypomagnesemia and acute myocardial infarction are listed contraindications to digoxin. Ongoing symptoms with a reduced ejection fraction despite optimized first-line therapy is the indication for digoxin, not a contraindication.
A nurse is teaching a client who is starting ivabradine. Which statement by the client shows understanding?
- "This drug will speed up my heart rate."
- "I will take it on an empty stomach with grapefruit juice."
- "I will take it with food, avoid grapefruit juice, and report feeling dizzy or an erratic heartbeat."
- "If I become pregnant, I can keep taking it."
Answer: "I will take it with food, avoid grapefruit juice, and report feeling dizzy or an erratic heartbeat."
Ivabradine must be taken with food, grapefruit juice is avoided, and dizziness or an erratic heartbeat is reported because it may relate to bradycardia or atrial fibrillation. It slows the heart rate and should not be taken in pregnancy.
Where every quote comes from
Section 19.6 Adjunct Medications Used in Heart Failure of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.