Pharmacology · chapter 19 · Heart Failure Drugs
Beta-Adrenergic Blockers
The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 6 practice questions with the reasoning.
Key points
What beta blockers do overall
In general, beta blockers decrease heart rate and contractility, decrease blood pressure, and may cause some bronchoconstriction. Select beta blockers have been found to decrease mortality in clients with heart failure (Heidenreich et al., 2022).
The three used in heart failure
Metoprolol and bisoprolol are two cardio-selective beta blockers, and carvedilol is a nonselective beta blocker that is used in the management of clients with heart failure.
Nonselective agents also vasodilate
Cardio-selective beta blockers affect the heart by reducing heart rate and contractility. Nonselective beta blockers affect the heart in the same way, but they also cause vasodilation due to their effects on alpha receptors of the arteries.
Slower rate means more filling time
If the heart rate is decreased, there is more time for diastole, or ventricular filling. Recall that coronary arteries deliver blood to the cardiac myocytes of the ventricles during diastole.
Lower afterload with nonselective agents
Nonselective beta blockers also decrease afterload, which means the heart does not have to produce as much force to generate stroke volume.
Serious adverse effects
Serious adverse effects include bradycardia, arrhythmias, hypoglycemia, and hypotension. Rare side effects include sexual and erectile dysfunction.
Check blood pressure and pulse first
Blood pressure and pulse rate should be monitored prior to administration. Beta blockers should not be administered if the client is hypotensive or has a heart rate less than 50–60 beats per minute, or as directed by the health care provider.
Nonselective agents and lung disease
Nonselective beta blockers are contraindicated in clients with moderate to severe asthma and/or chronic lung diseases due to the potential for causing an exacerbation.
Caution with AV node disease and bradycardia
Beta blockers should be used cautiously in clients with AV node and sinus bradycardia because they can aggravate these conditions.
Masked hypoglycemia in diabetes
Clients with diabetes should use beta blockers cautiously because they can mask the symptoms of hypoglycemia, causing confusion, fainting, or seizures.
Asthma plus a short-acting beta agonist
Safety Alert Beta Blockers Nonselective beta blockers should not be used in clients with asthma who are taking a short-acting beta agonist because they may cause worsening bronchospasm.
Watch for worsening heart failure
Monitor for symptoms of worsening heart failure such as fatigue, weight gain, and peripheral edema.
Herbal supplements to avoid
The client taking a beta-adrenergic blocker should not: Take beta-adrenergic blockers with OTC drugs or herbal supplements, such as ma-huang, ephedra, black cohosh, hawthorne, or licorice, without consulting their health care provider because these supplements may interfere with the action of the beta-adrenergic blocker.
Black box warning: taper, never stop abruptly
FDA Black Box Warning Beta-Adrenergic Blockers Beta blocker therapy should not be abruptly stopped, but gradually tapered to avoid exacerbation of angina and myocardial infarction.
Terms to know
- Beta-adrenergic blockers
- As presented in Antihypertensive and Antianginal Drugs, beta-adrenergic blockers (beta blocker s) are a classification of drugs that inhibit chronotropic, inotropic, and vasoconstrictor response to catecholamine, epinephrine, and norepinephrine.
- diastole
- If the heart rate is decreased, there is more time for diastole, or ventricular filling.
- afterload
- Nonselective beta blockers also decrease afterload, which means the heart does not have to produce as much force to generate stroke volume.
Practice questions
Stuck on select-all-that-apply? How to take them one option at a time.
The graded version needs JavaScript. Every question is below anyway, with the answer and why.
Every question here, with the answer
A client with heart failure is due for carvedilol. The nurse finds a blood pressure of 84/50 mm Hg and a heart rate of 58 beats per minute. What should the nurse do?
- Give the dose and have the client lie flat.
- Give the dose with a full glass of water.
- Withhold the dose and contact the health care provider.
- Give the dose and recheck vital signs in two hours.
Answer: Withhold the dose and contact the health care provider.
Blood pressure and pulse are checked before a beta blocker, and it should not be given to a hypotensive client or one with a heart rate under 50–60 beats per minute. This client is hypotensive with a borderline rate, so the dose is held and the provider contacted. The other options still give a drug that lowers blood pressure and heart rate further.
A client with heart failure also has moderate asthma and uses an albuterol inhaler as needed. The provider's order lists carvedilol. What is the nurse's priority concern?
- Carvedilol will raise the client's blood glucose.
- The client will need a higher dose of carvedilol because of asthma.
- A nonselective beta blocker may cause worsening bronchospasm in this client.
- Carvedilol will make the albuterol work faster.
Answer: A nonselective beta blocker may cause worsening bronchospasm in this client.
Carvedilol is nonselective, and nonselective beta blockers should not be used in clients with asthma taking a short-acting beta agonist because they may worsen bronchospasm. The other statements are not supported by the section.
A nurse is teaching a client with heart failure who is starting metoprolol succinate. Which instructions should the nurse include? Select all that apply.
- Check your blood glucose closely if you have diabetes.
- Take it only with a meal.
- Take your pulse before each dose as directed.
- Report weight gain and swelling in the feet or ankles.
- Stop the medication if you feel tired.
Answer: Check your blood glucose closely if you have diabetes., Take your pulse before each dose as directed., Report weight gain and swelling in the feet or ankles.
Clients take their pulse before the dose, watch for worsening heart failure such as weight gain and peripheral edema, and monitor glucose because beta blockers mask hypoglycemia. The drug must not be stopped abruptly, and it can be taken without regard to meals.
A client taking a beta blocker for heart failure says, "I feel better, so I'm going to stop these pills tomorrow." What is the nurse's best response?
- "That is fine once your symptoms are gone."
- "Skip every other day until you run out."
- "Cut the dose in half on your own for a week, then stop."
- "Stopping suddenly can worsen angina or cause a heart attack; talk to your provider, who can taper it."
Answer: "Stopping suddenly can worsen angina or cause a heart attack; talk to your provider, who can taper it."
The black box warning says beta blocker therapy should not be stopped abruptly but tapered gradually, and clients should seek provider advice before discontinuing. Stopping or self-tapering without the provider ignores that warning.
Which findings or conditions call for caution or are contraindications when giving a beta blocker? Select all that apply.
- Migraines
- Moderate to severe asthma with a nonselective agent
- Diabetes mellitus
- Controlled hypertension
- Sinus bradycardia
Answer: Moderate to severe asthma with a nonselective agent, Diabetes mellitus, Sinus bradycardia
Beta blockers can aggravate sinus bradycardia, mask hypoglycemia in diabetes, and nonselective agents are contraindicated in moderate to severe asthma. Hypertension and migraines are conditions beta blockers are used to treat.
A client with type 1 diabetes takes bisoprolol. Which statement by the client shows correct understanding?
- "Bisoprolol keeps my blood sugar from dropping."
- "My heart will race if my sugar drops, so I will notice it right away."
- "I may not feel the usual signs of low blood sugar, so I need to check my glucose closely."
- "I can stop checking my sugar while I take this pill."
Answer: "I may not feel the usual signs of low blood sugar, so I need to check my glucose closely."
Beta blockers block the sympathetic response that is activated when blood sugar is low, so they can mask hypoglycemia; clients should monitor glucose closely. The other statements assume normal warning signs or a protective effect that the drug does not have.
Where every quote comes from
Section 19.3 Beta-Adrenergic Blockers of Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris, Dorie Weaver, OpenStax, 2024. Read the whole section free at openstax.org.
The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.