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Fundamentals · chapter 23 · Neuromuscular Function

Factors Affecting Neuromuscular Functioning

The 14 things this section of the textbook says that you are most likely to be asked about — quoted word for word, not retold. Then 5 practice questions with the reasoning.

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Key points

  1. Diagnostic testing options

    There are several diagnostic tests that can be used to help diagnose specific neuromuscular disorders or rule out other conditions that may be causing similar symptoms.
  2. Blood test limitations

    No specific blood tests are available that diagnose disorders of the neuromuscular system with absolute certainty, however several tests are typically performed to assist with confirmation of the disorder or to rule out other causes.
  3. EMG muscle response

    An electromyography (EMG) is used to evaluate how muscles respond to nervous system stimulation.
  4. Imaging follow-up role

    The images obtained from these scans can help identify changes or abnormalities in muscle or nervous tissue that may be indicative of neuromuscular disorders. Although these tests are not usually conclusive for specific disorders, they can be used to show changes within the tissue that warrant additional follow-up and testing.
  5. NCV result interpretation

    If the NCV testing is normal, it is likely that the disorder has a muscular cause. On the other hand, if the NCV testing is abnormal (slow), the cause of the issue is more likely stemming from the nervous system.
  6. Muscle biopsy use

    However, it can be useful for determining specific types of muscle disorders if other tests come back inconclusive.
  7. Genetic testing accuracy

    This type of test is the most accurate for diagnosing neuromuscular disorders that are genetic in nature.
  8. CMT affected nerves

    CMT affects the peripheral nerves, most often those of the arms, hands, legs, and feet. As the disease progresses, the patient experiences worsening numbness and muscle weakness.
  9. Congenital myopathy severity

    These conditions are rare but serious because they result in lack of muscle tone and severe muscle weakness.
  10. Muscular dystrophy cause

    A group of muscular disorders called muscular dystrophy are caused by genetic mutations. All types of muscular dystrophies result in progressive muscle weakness.
  11. ALS progression effects

    As ALS progresses, more motor neurons die, resulting in muscle weakness, twitching, and atrophy. Eventually, ALS causes complete loss of control over voluntary movements including walking, talking, eating, and even breathing.
  12. Myasthenia gravis mechanism

    An autoimmune disorder, myasthenia gravis is a disorder in which antibodies attack the neuromuscular junction (NMJ) of skeletal muscles, resulting in progressive muscle weakness (e.g., arms, hands, fingers, legs, neck) and fatigue.
  13. MS exacerbation pattern

    In many cases, patients with MS have periods of exacerbation where symptoms are worse and periods of remission where symptoms improve temporarily.
  14. Spinal cord injury extent

    In some cases, the damage to the spinal cord is incomplete, leaving some sensation and mobility below the level of damage. However, in complete spinal cord injury, all feeling and ability to control movement are lost.

Terms to know

electromyography (EMG)
An electromyography (EMG) is used to evaluate how muscles respond to nervous system stimulation.
nerve conduction study, or nerve conduction velocity (NCV) testing
A nerve conduction study, or nerve conduction velocity (NCV) testing, shows how quickly electrical signals move through nerves in the body.
congenital myopathy
A genetic muscle deformity that is present from birth is called congenital myopathy.
motor neuron
A nerve cell that receives signals from the brain and spinal cord that cause voluntary skeletal muscle movements and breathing is called a motor neuron.
myelin
A neurological disorder, multiple sclerosis (MS) causes immune system cells to attack myelin, the protective coating on nerves.
cerebral palsy (CP)
An umbrella term for a group of disorders that affect the ability to move and stay balanced is cerebral palsy (CP), which occurs because of damage to the brain during pregnancy, childbirth, or in early infancy.
spinal cord injury
When there is damage to the spinal cord, a spinal cord injury occurs, often as a result of trauma (e.g., a motor vehicle accident, a fall) or cancer.
paralysis
This complete loss of sensation and mobility is called paralysis.

Practice questions

Stuck on select-all-that-apply? How to take them one option at a time.

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Every question here, with the answer

  1. A patient has muscle weakness and undergoes nerve conduction velocity (NCV) testing. The results are normal. Which interpretation is most consistent with this finding?

    1. The patient should be diagnosed with a complete spinal cord injury.
    2. The disorder is more likely stemming from the nervous system.
    3. The disorder is likely caused by a muscular problem.
    4. The patient has a confirmed diagnosis of multiple sclerosis.

    Answer: The disorder is likely caused by a muscular problem.

    The section states that normal NCV testing suggests a muscular cause, while slow or abnormal NCV testing suggests a nervous system cause. NCV testing can help guide the source of the problem, but it does not by itself confirm MS or spinal cord injury.

  2. A nurse is teaching a patient who will have electromyography (EMG). Which information should the nurse include? Select all that apply.

    1. Some patients report pain with needle insertion.
    2. The test evaluates how muscles respond to nervous system stimulation.
    3. The test usually takes sixty to ninety minutes.
    4. Lingering muscle soreness may occur for a few days after the procedure.
    5. The procedure typically causes severe pain for most patients.

    Answer: Some patients report pain with needle insertion., The test evaluates how muscles respond to nervous system stimulation., The test usually takes sixty to ninety minutes., Lingering muscle soreness may occur for a few days after the procedure.

    EMG is used to evaluate muscle response to nervous system stimulation and usually takes 60 to 90 minutes. The section notes that it typically does not cause much pain, although some patients report pain with needle insertion and lingering soreness for a few days.

  3. A patient newly diagnosed with relapsing-remitting multiple sclerosis asks what this subtype means. Which response by the nurse is most accurate?

    1. “This is the rarest subtype and includes steady worsening with acute relapses.”
    2. “This type occurs only after another MS subtype has already been diagnosed.”
    3. “Your symptoms will steadily worsen from the beginning without remission.”
    4. “Your symptoms occur as attacks, and between attacks they may improve or resolve completely.”

    Answer: “Your symptoms occur as attacks, and between attacks they may improve or resolve completely.”

    Relapsing-remitting MS is characterized by exacerbations or attacks followed by improvement or complete resolution during remission. The other options describe primary-progressive, secondary-progressive, and progressive-relapsing MS.

  4. A nurse is assessing an infant for early signs of cerebral palsy. Which findings are consistent with early signs listed in the section? Select all that apply.

    1. Overly stiff or floppy extremities
    2. Leg stiffening or scissoring when being picked up
    3. Eyelid drooping and double vision
    4. Inability to roll over after 6 months of age
    5. Head lag when being picked up from lying on the back

    Answer: Overly stiff or floppy extremities, Leg stiffening or scissoring when being picked up, Inability to roll over after 6 months of age, Head lag when being picked up from lying on the back

    The section lists head lag, overly stiff or floppy extremities, leg stiffening or scissoring, and inability to roll over after 6 months as early signs of cerebral palsy. Eyelid drooping and double vision are symptoms associated with myasthenia gravis, not early signs of cerebral palsy in this section.

  5. A nurse is reviewing possible diagnostic testing for a patient with suspected neuromuscular impairment. Which statements are accurate? Select all that apply.

    1. Electrolyte imbalances can cause muscle weakness or paralysis.
    2. Blood tests can assist with confirmation of a disorder or help rule out other causes.
    3. Genetic testing is the most accurate test for neuromuscular disorders that are genetic in nature.
    4. Muscle biopsy may be useful when other tests are inconclusive.
    5. CT and MRI scans are usually conclusive for specific neuromuscular disorders.

    Answer: Electrolyte imbalances can cause muscle weakness or paralysis., Blood tests can assist with confirmation of a disorder or help rule out other causes., Genetic testing is the most accurate test for neuromuscular disorders that are genetic in nature., Muscle biopsy may be useful when other tests are inconclusive.

    Blood tests can support confirmation or rule out other causes, and electrolyte imbalances can cause weakness or paralysis. Muscle biopsy can be useful if other tests are inconclusive, and genetic testing is most accurate for genetic neuromuscular disorders; CT and MRI are not usually conclusive for specific disorders.

Where every quote comes from

Section 23.2 Factors Affecting Neuromuscular Functioning of Fundamentals of Nursing by Christy Bowen, Lindsay Draper, Heather Moore, OpenStax, 2024. Read the whole section free at openstax.org.

The textbook is licensed under CC BY-NC-SA 4.0. This page quotes it word for word and adds the headings, the order and the practice questions; references to the book's figures and stray spaces left by its formatting are removed. The page is shared under the same licence. Nothing here is sold.